| Literature DB >> 1373520 |
D P Cerretti1, C J Kozlosky, B Mosley, N Nelson, K Van Ness, T A Greenstreet, C J March, S R Kronheim, T Druck, L A Cannizzaro.
Abstract
Interleukin-1 beta (IL-1 beta) mediates a wide range of immune and inflammatory responses. The active cytokine is generated by proteolytic cleavage of an inactive precursor. A complementary DNA encoding a protease that carries out this cleavage has been cloned. Recombinant expression in COS-7 cells enabled the cells to process precursor IL-1 beta to the mature form. Sequence analysis indicated that the enzyme itself may undergo proteolytic processing. The gene encoding the protease was mapped to chromosomal band 11q23, a site frequently involved in rearrangement in human cancers.Entities:
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Year: 1992 PMID： 1373520 DOI： 10.1126/science.1373520
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728