Literature DB >> 1373320

t(11;18)(q21;q21.1): a recurring translocation in lymphomas of mucosa-associated lymphoid tissue (MALT)?

D Horsman1, R Gascoyne, R Klasa, R Coupland.   

Abstract

A distinct subtype of extranodal malignant lymphoma derived from mucosa-associated lymphoid tissues (MALT) has recently been defined. We have detected an acquired t(11;18)(q21;q21.1) in a patient with a MALT lymphoma of the stomach. This translocation has previously been described in two other patients with extranodal lymphoma. The BCL2 oncogene, which is located at band 18q21.3 and is activated by the t(14;18)(q32;q21) in follicular lymphoma, was not rearranged in this case. This newly identified t(11;18) may be a recurring translocation specifically associated with MALT lymphomas. Genes located at the breakpoint sites of chromosome 11 and/or chromosome 18 may be crucial to the pathogenesis of this type of malignant lymphoma.

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Year:  1992        PMID： 1373320     DOI： 10.1002/gcc.2870040213

Source DB:  PubMed          Journal:  Genes Chromosomes Cancer        ISSN： 1045-2257            Impact factor:   5.006


  15 in total

1.  The product of the t(11;18), an API2-MLT fusion, marks nearly half of gastric MALT type lymphomas without large cell proliferation.

Authors:  M Baens; B Maes; A Steyls; K Geboes; P Marynen; C De Wolf-Peeters
Journal:  Am J Pathol       Date:  2000-04       Impact factor: 4.307

2.  Exclusive detection of the t(11;18)(q21;q21) in extranodal marginal zone B cell lymphomas (MZBL) of MALT type in contrast to other MZBL and extranodal large B cell lymphomas.

Authors:  A Rosenwald; G Ott; S Stilgenbauer; J Kalla; M Bredt; T Katzenberger; A Greiner; M M Ott; B Gawin; H Döhner; H K Müller-Hermelink
Journal:  Am J Pathol       Date:  1999-12       Impact factor: 4.307

3.  Trisomy 3 is not a common feature in malignant lymphomas of mucosa-associated lymphoid tissue type.

Authors:  G Ott; J Kalla; A Steinhoff; A Rosenwald; T Katzenberger; U Roblick; M M Ott; H K Müller-Hermelink
Journal:  Am J Pathol       Date:  1998-09       Impact factor: 4.307

Review 4.  From MALT lymphoma to the CBM signalosome: three decades of discovery.

Authors:  Shaun Rosebeck; Aasia O Rehman; Peter C Lucas; Linda M McAllister-Lucas
Journal:  Cell Cycle       Date:  2011-08-01       Impact factor: 4.534

5.  API2-MALT1 fusion transcripts involved in mucosa-associated lymphoid tissue lymphoma: multiplex RT-PCR detection using formalin-fixed paraffin-embedded specimens.

Authors:  H Inagaki; M Okabe; M Seto; S Nakamura; R Ueda; T Eimoto
Journal:  Am J Pathol       Date:  2001-02       Impact factor: 4.307

6.  Incidence and subtype specificity of API2-MALT1 fusion translocations in extranodal, nodal, and splenic marginal zone lymphomas.

Authors:  E D Remstein; C D James; P J Kurtin
Journal:  Am J Pathol       Date:  2000-04       Impact factor: 4.307

7.  Consistent copy number gain in chromosome 12 in primary diffuse large cell lymphomas of the stomach.

Authors:  W Y Chan; N Wong; A B Chan; J H Chow; J C Lee
Journal:  Am J Pathol       Date:  1998-01       Impact factor: 4.307

8.  Mucosa-associated lymphoid tissue lymphomas with t(11;18)(q21;q21) and mucosa-associated lymphoid tissue lymphomas with aneuploidy develop along different pathogenetic pathways.

Authors:  Ellen D Remstein; Paul J Kurtin; C David James; Xiao-Yang Wang; Reid G Meyer; Gordon W Dewald
Journal:  Am J Pathol       Date:  2002-07       Impact factor: 4.307

9.  18q21 Rearrangement and trisomy 3 in extranodal B-cell lymphomas: a study using a fluorescent in situ hybridisation technique.

Authors:  Yan-Chin Tai; Jin-Ai Mary Anne Tan; Suat-Cheng Peh
Journal:  Virchows Arch       Date:  2004-09-09       Impact factor: 4.064

10.  Primary gastric non-Hodgkin's lymphoma: a clinicopathological study of 41 patients.

Authors:  R Kath; K Donhuijsen; J Hayungs; K Albrecht; S Seeber; K Höffken
Journal:  J Cancer Res Clin Oncol       Date:  1995       Impact factor: 4.553
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