| Literature DB >> 1372673 |
A J Lategan1, M R Marien, F C Colpaert.
Abstract
Pretreatment of rats with the noradrenergic neurotoxin DSP-4 selectively reduced regional levels of noradrenaline in the brain by more than 75%, and decreased the concentration of endogenous DA in microdialysates of the caudate nucleus and nucleus accumbens by 52% and 28%, respectively. Results support the hypothesis that central noradrenergic mechanisms facilitate nigrostriatal and mesolimbic dopamine transmission in vivo.Entities:
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Year: 1992 PMID: 1372673 DOI: 10.1016/0024-3205(92)90093-5
Source DB: PubMed Journal: Life Sci ISSN: 0024-3205 Impact factor: 5.037