Literature DB >> 13724526

Selective localization of tetracycline in mitochondria of living cells.

H G DU BUY, J L SHOWACRE.   

Abstract

The property of tetracycline to induce fluorescence has been used to determine its localization in living cells. It was found that this antibiotic, as well as the related antibiotics oxytetracycline and chlorotetracycline, specifically combines with the mitochondria of living cells, either in tissue culture or in fresh preparations from various organs.

Entities:  

Keywords:  MITOCHONDRIA/metabolism; TETRACYCLINE/metabolism

Mesh：

Substances：

Year:  1961        PMID： 13724526     DOI： 10.1126/science.133.3447.196

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  23 in total

1.  TETRACYCLINE AND FATTY LIVER.

Authors:  L D WRUBLE; A J CUMMINS
Journal:  Am J Dig Dis       Date:  1965-08

2.  Absorption and transport of fluorescent brighteners by microorganisms.

Authors:  M A DARKEN
Journal:  Appl Microbiol       Date:  1962-09

3.  Incidence and detection of pleuropneumonia-like organisms in cell cultures by fluorescent antibody and cultural procedures.

Authors:  M F BARILE; W F MALIZIA; D B RIGGS
Journal:  J Bacteriol       Date:  1962-07       Impact factor: 3.490

4.  Interaction of molecular probes with living cells and tissues. Part 2. A structure-activity analysis of mitochondrial staining by cationic probes, and a discussion of the synergistic nature of image-based and biochemical approaches.

Authors:  F Rashid; R W Horobin
Journal:  Histochemistry       Date:  1990

5.  The migration of divalent cations in mitochondria visualized by a fluorescent chelate probe.

Authors:  A H Caswell
Journal:  J Membr Biol       Date:  1972-12       Impact factor: 1.843

6.  Phototoxicity of the tetracyclines: photosensitized emission of singlet delta dioxygen.

Authors:  T Hasan; A U Khan
Journal:  Proc Natl Acad Sci U S A       Date:  1986-07       Impact factor: 11.205

7.  Ultrastructure and dynamics of selective mitochondrial injury in carcinoma cells after doxycycline photosensitization in vitro.

Authors:  C R Shea; D Whitaker; G F Murphy; T Hasan
Journal:  Am J Pathol       Date:  1988-11       Impact factor: 4.307

8.  The effect of tetracycline on human liver cells in culture.

Authors:  A J Zuckerman; S F Baker; L J Dunkley
Journal:  Br J Exp Pathol       Date:  1968-02

9.  Tetracycline fluorescence as calcium-probe for nerve membrane with some model studies using erythrocyte ghosts.

Authors:  M Hallett; A S Schneider; E Carbone
Journal:  J Membr Biol       Date:  1972       Impact factor: 1.843

10.  The effect of vitamin B12 on tetracycline-induced fatty liver.

Authors:  T H Mikhail; K M Ibrahim; R Awadallah; E Mona
Journal:  Z Ernahrungswiss       Date:  1980-09
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