Literature DB >> 1372384

Dextran-magnetite particles: contrast-enhanced MRI of blood-brain barrier disruption in a rat model.

J W Bulte1, M W De Jonge, R L Kamman, K G Go, F Zuiderveen, B Blaauw, J A Oosterbaan, T H The, L de Leij.   

Abstract

Dextran-magnetite particles (DMP) were studied for their use as a MR contrast agent to visualize lesions with a blood-brain barrier (bbb) disruption. A freezing injury to the rat cerebral cortex was used as a model of bbb disruption. The biodistribution of iv-injected DMP was studied using atomic absorption spectrophotometry, electron microscopy, and MRI. One hour after injection, focal accumulation of the particles in capillary endothelial cells could be demonstrated in the freezing lesion. Despite the observation that the relaxivity of DMP in vivo appears to be less well pronounced than that in vitro, the MR imaging studies show that DMP can be used to visualize bbb disruption with adequate contrast.

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Year:  1992        PMID： 1372384     DOI： 10.1002/mrm.1910230203

Source DB:  PubMed          Journal:  Magn Reson Med        ISSN： 0740-3194            Impact factor:   4.668


  8 in total

1.  Development of Receptor Targeted Magnetic Iron Oxide Nanoparticles for Efficient Drug Delivery and Tumor Imaging.

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Journal:  J Biomed Nanotechnol       Date:  2008-12-01       Impact factor: 4.099

2.  Characterization of late radiation effects in the rat thoracolumbar spinal cord by MR imaging using USPIO.

Authors:  M E P Philippens; G Gambarota; J A Pikkemaat; W J M Peeters; A J van der Kogel; A Heerschap
Journal:  MAGMA       Date:  2004-12-21       Impact factor: 2.310

3.  Salicylic acid analogues as chemical exchange saturation transfer MRI contrast agents for the assessment of brain perfusion territory and blood-brain barrier opening after intra-arterial infusion.

Authors:  Xiaolei Song; Piotr Walczak; Xiaowei He; Xing Yang; Monica Pearl; Jeff W M Bulte; Martin G Pomper; Michael T McMahon; Mirosław Janowski
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4.  Magnetic resonance imaging of monocytes labeled with ultrasmall superparamagnetic particles of iron oxide using magnetoelectroporation in an animal model of multiple sclerosis.

Authors:  Raoul D Oude Engberink; Susanne M A van der Pol; Pjotr Walczak; Annette van der Toorn; Max A Viergever; Christine D Dijkstra; Jeff W M Bulte; Helga E de Vries; Erwin L A Blezer
Journal:  Mol Imaging       Date:  2010-10       Impact factor: 4.488

5.  Investigation of blood-brain barrier permeability to magnetite-dextran nanoparticles (MD3) after osmotic disruption in rats.

Authors:  V Rousseau; B Denizot; D Pouliquen; P Jallet; J J Le Jeune
Journal:  MAGMA       Date:  1997-09       Impact factor: 2.310

6.  Effect of MRI tags: SPIO nanoparticles and 19F nanoemulsion on various populations of mouse mesenchymal stem cells.

Authors:  Ghulam Muhammad; Anna Jablonska; Laura Rose; Piotr Walczak; Miroslaw Janowski
Journal:  Acta Neurobiol Exp (Wars)       Date:  2015       Impact factor: 1.579

Review 7.  Superparamagnetic iron oxides as MPI tracers: A primer and review of early applications.

Authors:  Jeff W M Bulte
Journal:  Adv Drug Deliv Rev       Date:  2018-12-13       Impact factor: 17.873

Review 8.  Perspective of Fe3O4 Nanoparticles Role in Biomedical Applications.

Authors:  Mohammad Reza Ghazanfari; Mehrdad Kashefi; Seyyedeh Fatemeh Shams; Mahmoud Reza Jaafari
Journal:  Biochem Res Int       Date:  2016-05-12
  8 in total

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