Literature DB >> 1372307

Microbial transformation of immunosuppressive compounds. I. Desmethylation of FK506 and immunomycin (FR 900520) by Actinoplanes sp. ATCC 53771.

T S Chen1, B H Arison, L S Wicker, E S Inamine, R L Monaghan.   

Abstract

The immunosuppressants FK506 and FR 900520 were desmethylated by Actinoplanes sp. ATCC 53771 to yield various O-desmethylated products. The products were isolated and purified by solvent extraction and HPLC chromatography, and identified by NMR and MS spectroscopy.

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Year:  1992        PMID： 1372307     DOI： 10.7164/antibiotics.45.118

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  3 in total

1.  Microbial Demethylation of Immunosuppressant FK-506: Isolation of 31-O-FK-506-Specific Demethylase Showing Cytochrome P-450 Characteristics from Streptomyces rimosus MA187.

Authors:  A Shafiee; T Chen; P Cameron
Journal:  Appl Environ Microbiol       Date:  1995-10       Impact factor: 4.792

2.  Microbial transformation of immunosuppressive compounds. III. Glucosylation of immunomycin (FR 900520) and FK 506 by Bacillus subtilis ATCC 55060.

Authors:  B R Petuch; B Arison; A Hsu; R Monaghan; F J Dumont; T S Chen
Journal:  J Ind Microbiol       Date:  1994-03

3.  Isolation, structure determination and biological activity of A-16686 factors A' 1, A' 2 and A' 3 glycolipodepsipeptide antibiotics.

Authors:  L Gastaldo; R Ciabatti; F Assi; E Restelli; J K Kettenring; L F Zerilli; G Romanò; M Denaro; B Cavalleri
Journal:  J Ind Microbiol       Date:  1992-11
  3 in total

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