Literature DB >> 1371671

Cyclic AMP-dependent modulation of cardiac Ca channels expressed in Xenopus laevis oocytes.

P Lory1, J Nargeot.   

Abstract

Cyclic AMP-dependent modulation of cardiac L-type voltage-dependent Ca channel (VDCC) has been probed in Xenopus laevis oocytes injected with poly(A+) RNA from rat heart. A 2 to 3 fold increase of the Ba current amplitude was routinely obtained upon microinjection of cAMP (50-500 microM). Inhibition of protein kinase A (PKA) dramatically reduced the Ba current amplitude, indicating that cAMP-dependent modulation plays an important role in maintaining the basal activity of expressed Ca channels. Moreover, the effects of the DHP agonist Bay K 8644 on kinetic properties of expressed Ba current (IBa,C) were dependent on PKA activation. The results suggest that most expressed cardiac L-type VDCCs are phosphorylated and demonstrate that reconstitution in Xenopus oocytes is a suitable approach to address how phosphorylation regulates VDCC activity.

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Year:  1992        PMID： 1371671     DOI： 10.1016/0006-291x(92)91839-i

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  10 in total

Review 1.  Regulation of L-type Ca2+ channels in the heart: overview of recent advances.

Authors:  Kaoru Yamaoka; Masaki Kameyama
Journal:  Mol Cell Biochem       Date:  2003-11       Impact factor: 3.396

2.  Ca2+-calmodulin-dependent protein kinase II represses cardiac transcription of the L-type calcium channel alpha(1C)-subunit gene (Cacna1c) by DREAM translocation.

Authors:  Jarkko J Ronkainen; Sandra L Hänninen; Topi Korhonen; Jussi T Koivumäki; Reka Skoumal; Sini Rautio; Veli-Pekka Ronkainen; Pasi Tavi
Journal:  J Physiol       Date:  2011-03-28       Impact factor: 5.182

3.  Modulation of the cloned skeletal muscle L-type Ca2+ channel by anchored cAMP-dependent protein kinase.

Authors:  B D Johnson; J P Brousal; B Z Peterson; P A Gallombardo; G H Hockerman; Y Lai; T Scheuer; W A Catterall
Journal:  J Neurosci       Date:  1997-02-15       Impact factor: 6.167

4.  Cyclic AMP-dependent regulation of P-type calcium channels expressed in Xenopus oocytes.

Authors:  F Fournier; E Bourinet; J Nargeot; P Charnet
Journal:  Pflugers Arch       Date:  1993-05       Impact factor: 3.657

5.  Protein kinase C regulation of cardiac calcium channels expressed in Xenopus oocytes.

Authors:  E Bourinet; F Fournier; P Lory; P Charnet; J Nargeot
Journal:  Pflugers Arch       Date:  1992-06       Impact factor: 3.657

6.  Regulation of the frequency-dependent facilitation of L-type Ca2+ currents in rat ventricular myocytes.

Authors:  F Tiaho; C Piot; J Nargeot; S Richard
Journal:  J Physiol       Date:  1994-06-01       Impact factor: 5.182

7.  cAMP-dependent phosphorylation sites and macroscopic activity of recombinant cardiac L-type calcium channels.

Authors:  G Mikala; U Klöckner; M Varadi; J Eisfeld; A Schwartz; G Varadi
Journal:  Mol Cell Biochem       Date:  1998-08       Impact factor: 3.396

8.  ATP and G proteins affect the runup of the Ca2+ current in bovine chromaffin cells.

Authors:  A Elhamdani; J L Bossu; A Feltz
Journal:  Pflugers Arch       Date:  1995-07       Impact factor: 3.657

9.  Reconstitution of β-adrenergic regulation of CaV1.2: Rad-dependent and Rad-independent protein kinase A mechanisms.

Authors:  Moshe Katz; Suraj Subramaniam; Orna Chomsky-Hecht; Vladimir Tsemakhovich; Veit Flockerzi; Enno Klussmann; Joel A Hirsch; Sharon Weiss; Nathan Dascal
Journal:  Proc Natl Acad Sci U S A       Date:  2021-05-25       Impact factor: 11.205

10.  The quest to identify the mechanism underlying adrenergic regulation of cardiac Ca2+ channels.

Authors:  Daniel Roybal; Jessica A Hennessey; Steven O Marx
Journal:  Channels (Austin)       Date:  2020-12       Impact factor: 2.581
  10 in total

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