Literature DB >> 1371602

Presynaptic modulation of amino acid release from synaptosomes.

A D Sherman1, T S Hegwood, S Baruah, R Waziri.   

Abstract

Using synaptosomes prepared from whole rat brain, the spontaneous, calcium-independent, and calcium-dependent release of glutamate and GABA was assessed. Time intervals of 1-30 seconds were studied. Spontaneous release of glutamate (but not GABA) was elevated by 10 microM NMDA or AMPA by thirty seconds. This stimulation was partially calcium-dependent. Calcium-dependent release induced by 30 mM KCl was biphasic, confirming previous findings. This release was stimulated at all time periods by the presence of 10 microM NMDA or AMPA in an antagonist-sensitive manner. These data suggest that glutamate and GABA are released from vesicular stores in rat synaptosomes and that some of this release is modulated by presynaptic glutamate receptors.

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Year:  1992        PMID： 1371602     DOI： 10.1007/bf00966789

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  31 in total

1.  Alpha-latrotoxin releases both vesicular and cytoplasmic glutamate from isolated nerve terminals.

Authors:  H T McMahon; L Rosenthal; J Meldolesi; D G Nicholls
Journal:  J Neurochem       Date:  1990-12       Impact factor: 5.372

2.  Two distinct mechanisms, differentially affected by excitatory amino acids, trigger GABA release from fetal mouse striatal neurons in primary culture.

Authors:  J P Pin; J Bockaert
Journal:  J Neurosci       Date:  1989-02       Impact factor: 6.167

3.  A rapid Percoll gradient procedure for isolation of synaptosomes directly from an S1 fraction: homogeneity and morphology of subcellular fractions.

Authors:  P R Dunkley; J W Heath; S M Harrison; P E Jarvie; P J Glenfield; J A Rostas
Journal:  Brain Res       Date:  1988-02-16       Impact factor: 3.252

4.  Transmitter glutamate release from isolated nerve terminals: evidence for biphasic release and triggering by localized Ca2+.

Authors:  H T McMahon; D G Nicholls
Journal:  J Neurochem       Date:  1991-01       Impact factor: 5.372

5.  Glutamine--a major substrate for nerve endings.

Authors:  H F Bradford; H K Ward; A J Thomas
Journal:  J Neurochem       Date:  1978-06       Impact factor: 5.372

6.  Rapid high-performance liquid chromatographic determination of amino acids in synaptosomal extracts.

Authors:  K Lenda; G Svenneby
Journal:  J Chromatogr       Date:  1980-10-24

7.  Kainic acid differentially affects the synaptosomal release of endogenous and exogenous amino acidic neurotransmitters.

Authors:  A Poli; A Contestabile; P Migani; L Rossi; C Rondelli; M Virgili; R Bissoli; O Barnabei
Journal:  J Neurochem       Date:  1985-12       Impact factor: 5.372

8.  4-Aminobutyrate can be released exocytotically from guinea-pig cerebral cortical synaptosomes.

Authors:  T S Sihra; D G Nicholls
Journal:  J Neurochem       Date:  1987-07       Impact factor: 5.372

9.  Glutamate receptor subtypes in cultured cerebellar neurons: modulation of glutamate and gamma-aminobutyric acid release.

Authors:  V Gallo; R Suergiu; C Giovannini; G Levi
Journal:  J Neurochem       Date:  1987-12       Impact factor: 5.372

10.  Glutamine and aspartate loading of synaptosomes: a reevaluation of effects on calcium-dependent excitatory amino acid release.

Authors:  H T McMahon; D G Nicholls
Journal:  J Neurochem       Date:  1990-02       Impact factor: 5.372
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  3 in total

Review 1.  Neuronal and glial localization of NMDA receptors in the cerebral cortex.

Authors:  F Conti; A Minelli; S DeBiasi; M Melone
Journal:  Mol Neurobiol       Date:  1997 Feb-Apr       Impact factor: 5.590

2.  Dual ultrastructural localization of mu-opioid receptors and NMDA-type glutamate receptors in the shell of the rat nucleus accumbens.

Authors:  K N Gracy; A L Svingos; V M Pickel
Journal:  J Neurosci       Date:  1997-06-15       Impact factor: 6.167

3.  Synaptosomal glutamate uptake in a model of experimental cerebral ischemia.

Authors:  G Zanchin; A De Boni; G Lauria; F Maggioni; P Rossi; A Villacara
Journal:  Neurochem Res       Date:  1995-02       Impact factor: 3.996
  3 in total

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