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Literature DB >> 137157

Axonal dwindling in early experimental diabetes. I. A study of cross sectioned nerves.

Abstract

A diminution of the cross sectional area of myelinated fibres in the common peroneal nerve was observed in rats four weeks after the induction of diabetes with streptozotocin. Small fibres were affected more than larger ones and the axon reduction was twice that of the myelin sheath. The fibre diminution and the decreased axon/myelin ratio may explain the slowing of nerve conduction in experimental diabetes.

Entities: Chemical Disease Species

Mesh：

Substances：
Streptozocin

Year: 1976 PMID： 137157 DOI： 10.1007/bf01220629

Source DB: PubMed Journal: Diabetologia ISSN： 0012-186X Impact factor: 10.122

15 in total

1. PATHOLOGICAL OBSERVATIONS ON SIX CASES OF DIABETIC NEUROPATHY.

Authors: D GREENBAUM; P C RICHARDSON; M V SALMON; H URICH
Journal: Brain Date: 1964-06 Impact factor: 13.501

2. A theory of the effects of fibre size in medullated nerve.

Authors: W A H RUSHTON
Journal: J Physiol Date: 1951-09 Impact factor: 5.182

3. Serial in vivo determinations of nerve conduction velocity in rat tails. Physiological and pathological changes.

Authors: T Miyoshi; I Goto
Journal: Electroencephalogr Clin Neurophysiol Date: 1973-08

4. Peripheral nerve structure and function in experimental diabetes.

Authors: A K Sharma; P K Thomas
Journal: J Neurol Sci Date: 1974-09 Impact factor: 3.181

5. Sural nerve myelinated fibre density and size in diabetics.

Authors: J S Chopra; L J Hurwitz
Journal: J Neurol Neurosurg Psychiatry Date: 1969-04 Impact factor: 10.154

6. Peripheral neuropathy in the alloxan-diabetic rat.

Authors: G M Preston
Journal: J Physiol Date: 1967-04 Impact factor: 5.182

7. Diabetic neuropathy: influence of age, sex, metabolic control, and duration of diabetes on motor conduction velocity.

Authors: G Gregersen
Journal: Neurology Date: 1967-10 Impact factor: 9.910

8. Effects of insulin and dietary myoinositol on impaired peripheral motor nerve conduction velocity in acute streptozotocin diabetes.

Authors: D A Greene; P V De Jesus; A I Winegrad
Journal: J Clin Invest Date: 1975-06 Impact factor: 14.808

9. Growth hormone in uremia. I. Plasma growth hormone, insulin and glucagon after oral and intravenous glucose in uremic subjects.

Authors: H Orskov; N J Christensen
Journal: Scand J Clin Lab Invest Date: 1971-02 Impact factor: 1.713

10. Axonal dwindling in early experimental diabetes. II. A study of isolated nerve fibres.

Authors: J Jakobsen
Journal: Diabetologia Date: 1976-12 Impact factor: 10.122

50 in total

1. Peripheral nerves in early experimental diabetes: expansion of the endoneurial space as a cause of increased water content.

Authors: J Jakobsen
Journal: Diabetologia Date: 1978-02 Impact factor: 10.122

2. A proposal for a classification of neuropathies according to their axonal transport abnormalities.

Authors: J Jakobsen; P Sidenius; H Braendgaard
Journal: J Neurol Neurosurg Psychiatry Date: 1986-09 Impact factor: 10.154

3. Histopathological heterogeneity of neuropathy in insulin-dependent and non-insulin-dependent diabetes, and demonstration of axo-glial dysjunction in human diabetic neuropathy.

Authors: A A Sima; V Nathaniel; V Bril; T A McEwen; D A Greene
Journal: J Clin Invest Date: 1988-02 Impact factor: 14.808

Review 4. Future treatments for diabetic neuropathy: clues from experimental neuropathy.

Authors: Nigel A Calcutt
Journal: Curr Diab Rep Date: 2002-12 Impact factor: 4.810

5. Sciatic nerve morphology and morphometry in mature rats with streptozocin-induced diabetes.

Authors: A Wright; H Nukada
Journal: Acta Neuropathol Date: 1994 Impact factor: 17.088

Review 6. The diabetic leg.

Authors: J D Ward
Journal: Diabetologia Date: 1982-03 Impact factor: 10.122

7. Sampling schemes for estimating nerve fibre size. II. Methods for unifascicular nerve trunks.

Authors: T M Mayhew; A K Sharma
Journal: J Anat Date: 1984-08 Impact factor: 2.610

8. Changes in peripheral nerves of rats four months after induction of streptozotocin diabetes. A qualitative and quantitative study.

Authors: G Bestetti; G L Rossi; C Zemp
Journal: Acta Neuropathol Date: 1981 Impact factor: 17.088

9. The polyol pathway. A historical review.

Authors: R S Clements
Journal: Drugs Date: 1986 Impact factor: 9.546

10. Peripheral neuropathy in the spontaneously diabetic BB-Wistar-rat. An ultrastructural study.

Authors: A A Sima
Journal: Acta Neuropathol Date: 1980 Impact factor: 17.088