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Literature DB >> 13713584

Endotoxin fever in granulocytopenic animals.

Abstract

The febrile response to bacterial endotoxin was measured in rabbits made leukopenic with nitrogen mustard. A striking increase in susceptibility to the lethal effects of endotoxin occurred in severely leukopenic animals. Animals without circulating granulocytes, or with only basophils, developed no significant fever after endotoxin injection. Animals with circulating granulocytes other than basophils exhibited a biphasic febrile response to endotoxin; this response was significantly less in magnitude than that of control animals. Control animals, severely granulocytopenic animals, and animals with no circulating granulocytes other than basophils showed comparable febrile responses to serum pyrogen. These results suggest that granulocytes inactivate endotoxin in vivo and support the hypothesis that leukocyte pyrogen is a necessary intermediate in endotoxin fever. Basophils do not appear to participate in this process. These observations also contradict previous studies that were taken to indicate a normal febrile response to endotoxin in leukopenic animals and suggest that those results are related to the persistence of granulocytes.

Entities: Chemical Disease Species

Keywords: AGRANULOCYTOSIS/experimental; FEVER/experimental; TOXINS AND ANTITOXINS/pharmacology

Mesh：

Substances：

Year: 1961 PMID： 13713584 PMCID： PMC2137422 DOI： 10.1084/jem.113.6.1115

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

17 in total

1. Studies on the pathogenesis of fever. III. Failure to demonstrate fever-producing substances in the tissues of leukopenic rabbits.

Authors: I L BENNETT
Journal: Bull Johns Hopkins Hosp Date: 1956-01

2. Studies on the pathogenesis of fever. VIII. Fever-producing substances in the serum of dogs.

Authors: R G PETERSDORF; I L BENNETT
Journal: J Exp Med Date: 1957-08-01 Impact factor: 14.307

3. Pathogenesis of fever: evidence for direct cerebral action of bacterial endotoxins.

Authors: I L BENNETT; R G PETERSDORF; W R KEENE
Journal: Trans Assoc Am Physicians Date: 1957

4. Resistance to experimental infection and mobilization of granulocytes in irradiated mice treated with bacterial endotoxin.

Authors: W W SMITH; I M ALDERMAN; R E GILLESPIE
Journal: Am J Physiol Date: 1958-02

5. Influence of nitrogen mustard upon reactions to bacterial endotoxins; Shwartzman phenomenon and fever.

Authors: I L BENNETT; L E CLUFF
Journal: Proc Soc Exp Biol Med Date: 1952-10

6. Studies on the pathogenesis of fever. II. Identification of an endogenous pyrogen in the blood stream following the injection of typhoid vaccine.

Authors: E ATKINS; W B WOOD
Journal: J Exp Med Date: 1955-11-01 Impact factor: 14.307

7. Studies on the pathogenesis of fever. III. The leucocytic origin of endogenous pyrogen in acute inflammatory exudates.

Authors: M K KING; W B WOOD
Journal: J Exp Med Date: 1958-02-01 Impact factor: 14.307

8. Studies on the pathogenesis of fever. IV. The site of action of leucocytic and circulating endogenous pyrogen.

Authors: M K KING; W B WOOD
Journal: J Exp Med Date: 1958-02-01 Impact factor: 14.307

9. Studies on the pathogenesis of fever. II. Characterization of fever-producing substances from polymorphonuclear leukocytes and from the fluid of sterile exudates.

Authors: I L BENNETT; P B BEESON
Journal: J Exp Med Date: 1953-11 Impact factor: 14.307

10. Studies on the pathogenesis of fever. I. The effect of injection of extracts and suspensions of uninfected rabbit tissues upon the body temperature of normal rabbits.

Authors: I L BENNETT; P B BEESON
Journal: J Exp Med Date: 1953-11 Impact factor: 14.307

12 in total

Review 1. THE SKIN AND SYSTEMIC INFECTIONS.

Authors: J A KENNEY
Journal: J Natl Med Assoc Date: 1964-11 Impact factor: 1.798

5. Mechanisms of endotoxin tolerance. IV. Specificity of the pyrogenic refractory state during continuous intravenous infusions of endotoxin.

Authors: S E Greisman; E J Young; W E Woodward
Journal: J Exp Med Date: 1966-11-01 Impact factor: 14.307

Endotoxin fever in granulocytopenic animals.

1. Studies on the pathogenesis of fever. III. Failure to demonstrate fever-producing substances in the tissues of leukopenic rabbits.

2. Studies on the pathogenesis of fever. VIII. Fever-producing substances in the serum of dogs.

3. Pathogenesis of fever: evidence for direct cerebral action of bacterial endotoxins.

4. Resistance to experimental infection and mobilization of granulocytes in irradiated mice treated with bacterial endotoxin.

5. Influence of nitrogen mustard upon reactions to bacterial endotoxins; Shwartzman phenomenon and fever.

6. Studies on the pathogenesis of fever. II. Identification of an endogenous pyrogen in the blood stream following the injection of typhoid vaccine.

7. Studies on the pathogenesis of fever. III. The leucocytic origin of endogenous pyrogen in acute inflammatory exudates.

8. Studies on the pathogenesis of fever. IV. The site of action of leucocytic and circulating endogenous pyrogen.

9. Studies on the pathogenesis of fever. II. Characterization of fever-producing substances from polymorphonuclear leukocytes and from the fluid of sterile exudates.

10. Studies on the pathogenesis of fever. I. The effect of injection of extracts and suspensions of uninfected rabbit tissues upon the body temperature of normal rabbits.

Review 1. THE SKIN AND SYSTEMIC INFECTIONS.

2. THE EFFECT OF GRANULOCYTOPENIA ON EXPERIMENTAL TUBERCULIN FEVER.

3. Distribution and clearance of circulating endotoxin.

4. Influence of antilymphocyte and antipolymorphonuclear sera on the pyrogenic effect of scarlet fever toxin.

5. Mechanisms of endotoxin tolerance. IV. Specificity of the pyrogenic refractory state during continuous intravenous infusions of endotoxin.

6. Experimental production of lethal Escherichia coli bacteremia of pelvic origin.

7. The mechanism of the pyrogenic effect of streptococcus cell wall mucopeptide.

8. Synovial inflammatory response to bacterial endotoxin.

9. STUDIES IN STAPHYLOCOCCAL FEVER. I. RESPONSES TO BACTERIAL CELLS.

10. Release of an endogenous pyrogen in vitro from rabbit mononuclear cells.