Literature DB >> 1370581

Termination of second messenger signaling in olfaction.

I Boekhoff1, H Breer.   

Abstract

By using isolated rat olfactory cilia and a fast kinetics methodology, it has been demonstrated that odorant-induced second messenger signaling in the millisecond time range is terminated via phosphorylation reactions catalyzed by specific protein kinases. The cyclic adenosine nucleotide pathway is turned off by kinase A activity, whereas the inositol trisphosphate cascade is terminated by kinase C. The data support the concept that desensitization of odorant responses involves phosphorylation of key elements in the transduction cascade.

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Year:  1992        PMID： 1370581      PMCID： PMC48260          DOI： 10.1073/pnas.89.2.471

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  20 in total

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Journal:  Annu Rev Neurosci       Date:  1986       Impact factor: 12.449

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Journal:  J Neurosci       Date:  1986-08       Impact factor: 6.167

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Authors:  S Firestein; F Werblin
Journal:  Science       Date:  1989-04-07       Impact factor: 47.728

5.  Ca2(+)-dependent adaptive properties in the solitary olfactory receptor cell of the newt.

Authors:  T Kurahashi; T Shibuya
Journal:  Brain Res       Date:  1990-05-07       Impact factor: 3.252

6.  Radioimmunoassay for cyclic nucleotides. II. Adenosine 3',5'-monophosphate and guanosine 3',5'-monophosphate in mammalian tissues and body fluids.

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Journal:  J Biol Chem       Date:  1971-04-10       Impact factor: 5.157

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Authors:  P A Liebman; E N Pugh
Journal:  Nature       Date:  1980-10-23       Impact factor: 49.962

9.  Odorant-sensitive adenylate cyclase: rapid, potent activation and desensitization in primary olfactory neuronal cultures.

Authors:  G V Ronnett; D J Parfitt; L D Hester; S H Snyder
Journal:  Proc Natl Acad Sci U S A       Date:  1991-03-15       Impact factor: 11.205

10.  Odorant signal termination by olfactory UDP glucuronosyl transferase.

Authors:  D Lazard; K Zupko; Y Poria; P Nef; J Lazarovits; S Horn; M Khen; D Lancet
Journal:  Nature       Date:  1991-02-28       Impact factor: 49.962
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  29 in total

1.  Olfactory adaptation depends on the Trp Ca2+ channel in Drosophila.

Authors:  K F Störtkuhl; B T Hovemann; J R Carlson
Journal:  J Neurosci       Date:  1999-06-15       Impact factor: 6.167

2.  Ca2+-activated K+ currents regulate odor adaptation by modulating spike encoding of olfactory receptor cells.

Authors:  Fusao Kawai
Journal:  Biophys J       Date:  2002-04       Impact factor: 4.033

3.  Olfactory transduction is intrinsically noisy.

Authors:  G Lowe; G H Gold
Journal:  Proc Natl Acad Sci U S A       Date:  1995-08-15       Impact factor: 11.205

4.  Phosphorylation of mammalian olfactory cyclic nucleotide-gated channels increases ligand sensitivity.

Authors:  F Müller; W Bönigk; F Sesti; S Frings
Journal:  J Neurosci       Date:  1998-01-01       Impact factor: 6.167

5.  The cyclic nucleotide-activated conductance in olfactory cilia: effects of cytoplasmic Mg2+ and Ca2+.

Authors:  S J Kleene
Journal:  J Membr Biol       Date:  1993-02       Impact factor: 1.843

6.  Role of protein kinase C in light adaptation of molluscan microvillar photoreceptors.

Authors:  Giuseppe Piccoli; Maria Del Pilar Gomez; Enrico Nasi
Journal:  J Physiol       Date:  2002-09-01       Impact factor: 5.182

7.  Odorant-stimulated phosphoinositide signaling in mammalian olfactory receptor neurons.

Authors:  K Klasen; E A Corey; F Kuck; C H Wetzel; H Hatt; B W Ache
Journal:  Cell Signal       Date:  2009-09-22       Impact factor: 4.315

8.  Odor-induced phosphorylation of olfactory cilia proteins.

Authors:  I Boekhoff; S Schleicher; J Strotmann; H Breer
Journal:  Proc Natl Acad Sci U S A       Date:  1992-12-15       Impact factor: 11.205

9.  Human olfactory neurons respond to odor stimuli with an increase in cytoplasmic Ca2+.

Authors:  D Restrepo; Y Okada; J H Teeter; L D Lowry; B Cowart; J G Brand
Journal:  Biophys J       Date:  1993-06       Impact factor: 4.033

10.  Phosphodiesterase 1C is dispensable for rapid response termination of olfactory sensory neurons.

Authors:  Katherine D Cygnar; Haiqing Zhao
Journal:  Nat Neurosci       Date:  2009-03-22       Impact factor: 24.884
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