Literature DB >> 1370531

Phospholipase C-gamma 1 association with CD3 structure in T cells.

J D Dasgupta1, C Granja, B Druker, L L Lin, E J Yunis, V Relias.   

Abstract

Recently, we and others have reported tyrosine phosphorylation of phospholipase C-gamma 1 (PLC gamma 1) enzyme after CD3 activation of T cells, and have proposed that PLC gamma 1 mediates signal transduction through the T cell receptor (TCR/CD3). Here, using immunoblotting and immune complex PLC assays, we show that CD3 stimulation of Jurkat cells induces the association of PLC gamma 1 enzyme with CD3 complex. PLC activity is also found to co-precipitate with the CD3 zeta chain from activated cells. In addition, in vitro PLC assays show that CD3 activation leads to about 10-fold stimulation of PLC gamma 1 activity. These results, along with the observation that Jurkat cells preferentially express PLC gamma 1, indicate that PLC gamma 1 participates in CD3 signaling.

Entities:  

Mesh：

Substances：

Year:  1992        PMID： 1370531      PMCID： PMC2119075          DOI： 10.1084/jem.175.1.285

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  21 in total

1.  Activation of tyrosine phosphorylation in human T cells via the CD2 pathway. Regulation by the CD45 tyrosine phosphatase.

Authors:  L E Samelson; M C Fletcher; J A Ledbetter; C H June
Journal:  J Immunol       Date:  1990-10-15       Impact factor: 5.422

2.  Platelet-derived growth factor (PDGF) binding promotes physical association of PDGF receptor with phospholipase C.

Authors:  D A Kumjian; M I Wahl; S G Rhee; T O Daniel
Journal:  Proc Natl Acad Sci U S A       Date:  1989-11       Impact factor: 11.205

3.  Association of the fyn protein-tyrosine kinase with the T-cell antigen receptor.

Authors:  L E Samelson; A F Phillips; E T Luong; R D Klausner
Journal:  Proc Natl Acad Sci U S A       Date:  1990-06       Impact factor: 11.205

4.  Multiple kinases and signal transduction. Phosphorylation of the T cell antigen receptor complex.

Authors:  M D Patel; L E Samelson; R D Klausner
Journal:  J Biol Chem       Date:  1987-04-25       Impact factor: 5.157

5.  T-cell antigen receptor ligation induces tyrosine phosphorylation of phospholipase C-gamma 1.

Authors:  J P Secrist; L Karnitz; R T Abraham
Journal:  J Biol Chem       Date:  1991-07-05       Impact factor: 5.157

6.  EGF induces tyrosine phosphorylation of phospholipase C-II: a potential mechanism for EGF receptor signaling.

Authors:  B Margolis; S G Rhee; S Felder; M Mervic; R Lyall; A Levitzki; A Ullrich; A Zilberstein; J Schlessinger
Journal:  Cell       Date:  1989-06-30       Impact factor: 41.582

7.  Functional activation of the T-cell antigen receptor induces tyrosine phosphorylation of phospholipase C-gamma 1.

Authors:  A Weiss; G Koretzky; R C Schatzman; T Kadlecek
Journal:  Proc Natl Acad Sci U S A       Date:  1991-07-01       Impact factor: 11.205

8.  Tyrosine kinase activity is essential for the association of phospholipase C-gamma with the epidermal growth factor receptor.

Authors:  B Margolis; F Bellot; A M Honegger; A Ullrich; J Schlessinger; A Zilberstein
Journal:  Mol Cell Biol       Date:  1990-02       Impact factor: 4.272

9.  PDGF stimulation of inositol phospholipid hydrolysis requires PLC-gamma 1 phosphorylation on tyrosine residues 783 and 1254.

Authors:  H K Kim; J W Kim; A Zilberstein; B Margolis; J G Kim; J Schlessinger; S G Rhee
Journal:  Cell       Date:  1991-05-03       Impact factor: 41.582

10.  PLC gamma 1, a possible mediator of T cell receptor function.

Authors:  C Granja; L L Lin; E J Yunis; V Relias; J D Dasgupta
Journal:  J Biol Chem       Date:  1991-09-05       Impact factor: 5.157
View more
  8 in total

Review 1.  Cellular signalling mechanisms in B lymphocytes.

Authors:  W Cushley; M M Harnett
Journal:  Biochem J       Date:  1993-06-01       Impact factor: 3.857

2.  CD4-independent signal transduction through the T-cell receptor (TCR/CD3).

Authors:  C B Granja; C S Gozashti; J D Dasgupta
Journal:  Immunology       Date:  1994-11       Impact factor: 7.397

3.  Functional independence and interdependence of the Src homology domains of phospholipase C-gamma1 in B-cell receptor signal transduction.

Authors:  K E DeBell; B A Stoica; M C Verí; A Di Baldassarre; S Miscia; L J Graham; B L Rellahan; M Ishiai; T Kurosaki; E Bonvini
Journal:  Mol Cell Biol       Date:  1999-11       Impact factor: 4.272

4.  Activation of phospholipase C-gamma 1 through transfected platelet-derived growth factor receptor enhances interleukin 2 production upon antigen stimulation in a T-cell line.

Authors:  H Nakano; H Ohno; T Saito
Journal:  Mol Cell Biol       Date:  1994-02       Impact factor: 4.272

5.  G-proteins are not directly involved in the CD3-antigen-mediated production of inositol phosphates in HPB-ALL T-leukaemia cells expressing phospholipase C isoforms gamma 1 and beta 3.

Authors:  M Biffen; M Shiroo; D R Alexander
Journal:  Biochem J       Date:  1993-01-15       Impact factor: 3.857

6.  Cyclosporin A inhibits CD40 ligand expression in T lymphocytes.

Authors:  R Fuleihan; N Ramesh; A Horner; D Ahern; P J Belshaw; D G Alberg; I Stamenkovic; W Harmon; R S Geha
Journal:  J Clin Invest       Date:  1994-03       Impact factor: 14.808

7.  CD45 tyrosine phosphatase-activated p59fyn couples the T cell antigen receptor to pathways of diacylglycerol production, protein kinase C activation and calcium influx.

Authors:  M Shiroo; L Goff; M Biffen; E Shivnan; D Alexander
Journal:  EMBO J       Date:  1992-12       Impact factor: 11.598

8.  Association of the tyrosine kinase LCK with phospholipase C-gamma 1 after stimulation of the T cell antigen receptor.

Authors:  J R Weber; G M Bell; M Y Han; T Pawson; J B Imboden
Journal:  J Exp Med       Date:  1992-08-01       Impact factor: 14.307
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.