Literature DB >> 13702029

The effect of aminomethylpteroylglutamic acid on the development of skin hypersensitivity and on antibody formation in guinea pigs.

R M FRIEDMAN, C E BUCKLER, S BARON.   

Abstract

1. In guinea pigs, aminomethylpteroylglutamic acid (methotrexate) is capable of blocking the development of delayed skin hypersensitivity, the primary antibody response, and the specific febrile response to ovalbumin and diphtheria toxoid. The primary antibody response is more easily inhibited than is the development of delayed skin hypersensitivity. 2. The effect of methotrexate on immunologic responses depended upon the dose of methotrexate employed and the strength of the antigenic stimulus.

Entities:  

Keywords:  ANTIBODIES; FOLIC ACID ANTAGONISTS/pharmacology; SKIN/pharmacology

Mesh：

Substances：

Year:  1961        PMID： 13702029      PMCID： PMC2137449          DOI： 10.1084/jem.114.2.173

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  17 in total

1.  Effect of 8-azaguanine on antibody synthesis in vitro.

Authors:  R W DUTTON; A H DUTTON; M GEORGE
Journal:  Nature       Date:  1958-11-15       Impact factor: 49.962

2.  The effect of 5-bromouracil deoxyriboside on the synthesis of antibody in vitro.

Authors:  R W DUTTON; A H DUTTON; J H VAUGHAN
Journal:  Biochem J       Date:  1960-05       Impact factor: 3.857

3.  Alteration of homograft reaction by A-methopterin in lethally irradiated mice treated with homologous marrow.

Authors:  D E UPHOFF
Journal:  Proc Soc Exp Biol Med       Date:  1958-12

4.  Folic acid coenzymes.

Authors:  F M HUENNEKENS; M J OSBORN; H R WHITELEY
Journal:  Science       Date:  1958-07-18       Impact factor: 47.728

5.  Growth of cells in vivo in diffusion chambers. I. Survival of homografts in immunized mice.

Authors:  G H ALGIRE; J M WEAVER; R T PREHN
Journal:  J Natl Cancer Inst       Date:  1954-12       Impact factor: 13.506

6.  The effect of pteroylglutamic acid on some immune responses of chicks.

Authors:  P A LITTLE; J J OLESON; P K ROESCH
Journal:  J Immunol       Date:  1950-11       Impact factor: 5.422

7.  Complement-fixing murine typhus antibodies in vitamin deficiency states. III. Riboflavin and folic acid deficiencies.

Authors:  K WERTMANN; F D CRISLEY; J L SARANDRIA
Journal:  Proc Soc Exp Biol Med       Date:  1952-07

8.  Delayed hypersensitivity. IV. Systemic reactivity of guinea pigs sensitized to protein antigens.

Authors:  J W UHR; M W BRANDRISS
Journal:  J Exp Med       Date:  1958-12-01       Impact factor: 14.307

9.  Delayed hypersensitivity in the development of circulating antibody; the effect of x-irradiation.

Authors:  S B SALVIN; R F SMITH
Journal:  J Exp Med       Date:  1959-04-01       Impact factor: 14.307

10.  Occurrence of delayed hypersensitivity during the development of Arthus type hypersensitivity.

Authors:  S B SALVIN
Journal:  J Exp Med       Date:  1958-01-01       Impact factor: 14.307
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  12 in total

1.  STUDIES ON THE SUPPRESSION OF IMMUNE RESPONSES BY THE PERIWINKLE ALKALOIDS VINCRISTINE AND VINBLASTINE.

Authors:  A C AISENBERG; B WILES
Journal:  J Clin Invest       Date:  1964-12       Impact factor: 14.808

2.  THE EFFECT OF DELAYED ADMINISTRATION OF FOLINIC ACID ON IMMUNOLOGICAL INHIBITION BY METHOTREXATE.

Authors:  M C BERENBAUM; I N BROWN
Journal:  Immunology       Date:  1965-03       Impact factor: 7.397

Review 3.  Suppression of the immune response.

Authors:  J Bradley; C J Elson
Journal:  J Med Genet       Date:  1971-09       Impact factor: 6.318

4.  The effect of high dosage of methotrexate, associated with folinic acid, on the suppression of tuberculin sensitivity in guinea-pigs.

Authors:  P D Hart; R J Rees; J S Niven
Journal:  Clin Exp Immunol       Date:  1968-01       Impact factor: 4.330

5.  In vitro correlates of delayed hypersensitivity in tuberculosis.

Authors:  I C Verma
Journal:  Indian J Pediatr       Date:  1970-07       Impact factor: 1.967

6.  Effect of methotrexate on the response of rat lymphocytes to phytohaemagglutinin.

Authors:  A Mansour; J A Henderson; D S Nelson
Journal:  Clin Exp Immunol       Date:  1978-12       Impact factor: 4.330

7.  Role of the thymus in tolerance. I. Tolerance to bovine gamma globulin in thymectomized, irradiated rats grafted with thymus from tolerant donors.

Authors:  K Isaković; S B Smith; B H Waksman
Journal:  J Exp Med       Date:  1965-12-01       Impact factor: 14.307

8.  Immunosuppressive therapy in polymyositis.

Authors:  S Currie; J N Walton
Journal:  J Neurol Neurosurg Psychiatry       Date:  1971-08       Impact factor: 10.154

9.  The effect of 6-mercaptopurine on delayed hypersensitivity in guinea pigs.

Authors:  J R HOYER; L W HOYER; R A GOOD; R M CONDIE
Journal:  J Exp Med       Date:  1962-11-01       Impact factor: 14.307

10.  THE EFFECT OF 6-MERCAPTOPURINE AND AMINOPTERIN ON EXPERIMENTAL IMMUNE THYROIDITIS IN GUINEA PIGS.

Authors:  H L SPIEGELBERG; P A MIESCHER
Journal:  J Exp Med       Date:  1963-11-01       Impact factor: 14.307
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