Literature DB >> 1370094

A CD4+ cytotoxic T-lymphocyte clone to a conserved epitope on human immunodeficiency virus type 1 p24: cytotoxic activity and secretion of interleukin-2 and interleukin-6.

R A Littaua1, M B Oldstone, A Takeda, F A Ennis.   

Abstract

A CD4+ cytotoxic T-lymphocyte (CTL) clone, established from the peripheral blood of a human immunodeficiency virus (HIV)-seropositive donor, lysed autologous target cells that were infected with a recombinant vaccinia virus containing the gag gene of HIV type 1 and target cells pulsed with p24gag construct expressed in Escherichia coli. The recognition of the HLA-DQ-restricted epitope by this clone was further defined by using overlapping synthetic peptides. The epitope recognized by this CD4+ CTL clone (amino acids 140 to 148) overlaps with a CD8+ epitope and is highly conserved among all isolates of HIV type 1 that have been sequenced. Production and secretion of lymphokines such as interleukin-2 and interleukin-6 after specific antigenic stimulation were demonstrated by this gag-specific CD4+ CTL clone.

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Year:  1992        PMID： 1370094      PMCID： PMC238325     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  19 in total

Review 1.  Functional diversity of T lymphocytes due to secretion of different cytokine patterns.

Authors:  N E Street; T R Mosmann
Journal:  FASEB J       Date:  1991-02       Impact factor: 5.191

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Authors:  S G Marsh; J G Bodmer
Journal:  Tissue Antigens       Date:  1991-04

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Journal:  Cell       Date:  1984-01       Impact factor: 41.582

4.  Cytotoxic t cells in cytomegalovirus infection: HLA-restricted T-lymphocyte and non-T-lymphocyte cytotoxic responses correlate with recovery from cytomegalovirus infection in bone-marrow-transplant recipients.

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Journal:  N Engl J Med       Date:  1982-07-01       Impact factor: 91.245

Review 5.  Cytotoxic T lymphocytes against HIV.

Authors:  B D Walker; F Plata
Journal:  AIDS       Date:  1990-03       Impact factor: 4.177

6.  An HLA-C-restricted CD8+ cytotoxic T-lymphocyte clone recognizes a highly conserved epitope on human immunodeficiency virus type 1 gag.

Authors:  R A Littaua; M B Oldstone; A Takeda; C Debouck; J T Wong; C U Tuazon; B Moss; F Kievits; F A Ennis
Journal:  J Virol       Date:  1991-08       Impact factor: 5.103

7.  Phenotypic heterogeneity of cerebrospinal fluid-derived HIV-specific and HLA-restricted cytotoxic T-cell clones.

Authors:  K K Sethi; H Näher; I Stroehmann
Journal:  Nature       Date:  1988-09-08       Impact factor: 49.962

8.  Influenza virus-specific human cytotoxic T cell clones: heterogeneity in antigenic specificity and restriction by class II MHC products.

Authors:  D R Kaplan; R Griffith; V L Braciale; T J Braciale
Journal:  Cell Immunol       Date:  1984-10-01       Impact factor: 4.868

9.  Human cytotoxic T cell clones directed against herpes simplex virus-infected cells. I. Lysis restricted by HLA class II MB and DR antigens.

Authors:  M Yasukawa; J M Zarling
Journal:  J Immunol       Date:  1984-07       Impact factor: 5.422

10.  An immunodominant class I-restricted cytotoxic T lymphocyte determinant of human immunodeficiency virus type 1 induces CD4 class II-restricted help for itself.

Authors:  H Takahashi; R N Germain; B Moss; J A Berzofsky
Journal:  J Exp Med       Date:  1990-02-01       Impact factor: 14.307
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  20 in total

1.  Mutation of human immunodeficiency virus type 1 at amino acid 585 on gp41 results in loss of killing by CD8+ A24-restricted cytotoxic T lymphocytes.

Authors:  L C Dai; K West; R Littaua; K Takahashi; F A Ennis
Journal:  J Virol       Date:  1992-05       Impact factor: 5.103

Review 2.  The physiological role of cytotoxic CD4(+) T-cells: the holy grail?

Authors:  V Appay
Journal:  Clin Exp Immunol       Date:  2004-10       Impact factor: 4.330

3.  Control of vaccinia virus skin lesions by long-term-maintained IFN-gamma+TNF-alpha+ effector/memory CD4+ lymphocytes in humans.

Authors:  Bénédicte Puissant-Lubrano; Philippe Bossi; Frederick Gay; Jean-Marc Crance; Olivia Bonduelle; Daniel Garin; François Bricaire; Brigitte Autran; Behazine Combadière
Journal:  J Clin Invest       Date:  2010-04-01       Impact factor: 14.808

4.  Multiple effector functions mediated by human immunodeficiency virus-specific CD4(+) T-cell clones.

Authors:  P J Norris; M Sumaroka; C Brander; H F Moffett; S L Boswell; T Nguyen; Y Sykulev; B D Walker; E S Rosenberg
Journal:  J Virol       Date:  2001-10       Impact factor: 5.103

5.  Cytotoxic activity against maedi-visna virus-infected macrophages.

Authors:  W C Lee; I McConnell; B A Blacklaws
Journal:  J Virol       Date:  1994-12       Impact factor: 5.103

6.  Human immunodeficiency virus type 1-specific cytotoxic T lymphocytes release gamma interferon, tumor necrosis factor alpha (TNF-alpha), and TNF-beta when they encounter their target antigens.

Authors:  C Jassoy; T Harrer; T Rosenthal; B A Navia; J Worth; R P Johnson; B D Walker
Journal:  J Virol       Date:  1993-05       Impact factor: 5.103

7.  Major histocompatibility complex-restricted CD8+ cytotoxic T lymphocytes from horses with equine infectious anemia virus recognize Env and Gag/PR proteins.

Authors:  T C McGuire; D B Tumas; K M Byrne; M T Hines; S R Leib; A L Brassfield; K I O'Rourke; L E Perryman
Journal:  J Virol       Date:  1994-03       Impact factor: 5.103

8.  Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome.

Authors:  R A Koup; J T Safrit; Y Cao; C A Andrews; G McLeod; W Borkowsky; C Farthing; D D Ho
Journal:  J Virol       Date:  1994-07       Impact factor: 5.103

9.  Identification of T-cell epitopes on E2 protein of rubella virus, as recognized by human T-cell lines and clones.

Authors:  D Ou; P Chong; Y Choi; P McVeigh; W A Jefferies; G Koloitis; A J Tingle; S Gillam
Journal:  J Virol       Date:  1992-11       Impact factor: 5.103

10.  Characterization of human immunodeficiency virus type 1 (HIV-1) Gag- and Gag peptide-specific CD4(+) T-cell clones from an HIV-1-seronegative donor following in vitro immunization.

Authors:  Sara Venturini; Donald E Mosier; Dennis R Burton; Pascal Poignard
Journal:  J Virol       Date:  2002-07       Impact factor: 5.103
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