Literature DB >> 1370093

p53 shares an antigenic determinant with proteins of 92 and 150 kilodaltons that may be involved in senescence of human cells.

S J van den Heuvel1, S I The, B Klein, A G Jochemsen, A Zantema, A J van der Eb.   

Abstract

A panel of primary human cells and virus-transformed derivatives were tested for events that coincide with immortalization. In all primary and precrisis cells, two proteins of 92 and 150 kDa that shared an epitope with p53 were found; in most of their immortalized derivatives, however, they were absent. Expression of these proteins may be involved in senescence.

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Year:  1992        PMID： 1370093      PMCID： PMC238322     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  21 in total

Review 1.  Genetic and molecular studies of cellular immortalization.

Authors:  J R Smith; O M Pereira-Smith
Journal:  Adv Cancer Res       Date:  1990       Impact factor: 6.242

Review 2.  In vitro transformation of human epithelial cells.

Authors:  S E Chang
Journal:  Biochim Biophys Acta       Date:  1986

3.  Failure to phosphorylate the retinoblastoma gene product in senescent human fibroblasts.

Authors:  G H Stein; M Beeson; L Gordon
Journal:  Science       Date:  1990-08-10       Impact factor: 47.728

4.  Synthesis of DNA polymerase alpha analyzed by immunoprecipitation from synchronously proliferating cells.

Authors:  P Thömmes; T Reiter; R Knippers
Journal:  Biochemistry       Date:  1986-03-25       Impact factor: 3.162

5.  Comparative two-dimensional gel analysis and microsequencing identifies gelsolin as one of the most prominent downregulated markers of transformed human fibroblast and epithelial cells.

Authors:  J Vandekerckhove; G Bauw; K Vancompernolle; B Honoré; J Celis
Journal:  J Cell Biol       Date:  1990-07       Impact factor: 10.539

6.  Isolation and characterization of four adenovirus type 12-transformed human embryo kidney cell lines.

Authors:  J L Whittaker; P J Byrd; R J Grand; P H Gallimore
Journal:  Mol Cell Biol       Date:  1984-01       Impact factor: 4.272

7.  Monoclonal antibodies against simian virus 40 T antigens: evidence for distinct sublcasses of large T antigen and for similarities among nonviral T antigens.

Authors:  E G Gurney; R O Harrison; J Fenno
Journal:  J Virol       Date:  1980-06       Impact factor: 5.103

8.  Detection of a common feature in several human tumor cell lines--a 53,000-dalton protein.

Authors:  L V Crawford; D C Pim; E G Gurney; P Goodfellow; J Taylor-Papadimitriou
Journal:  Proc Natl Acad Sci U S A       Date:  1981-01       Impact factor: 11.205

9.  Association between the cellular p53 and the adenovirus 5 E1B-55kd proteins reduces the oncogenicity of Ad-transformed cells.

Authors:  S J van den Heuvel; T van Laar; W M Kast; C J Melief; A Zantema; A J van der Eb
Journal:  EMBO J       Date:  1990-08       Impact factor: 11.598

10.  Monoclonal antibodies against simian virus 40 nuclear large T tumour antigen: epitope mapping, papova virus cross-reaction and cell surface staining.

Authors:  R K Ball; B Siegl; S Quellhorst; G Brandner; D G Braun
Journal:  EMBO J       Date:  1984-07       Impact factor: 11.598
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  3 in total

1.  Efficient Transformation of Primary Human Mesenchymal Stromal Cells by Adenovirus Early Region 1 Oncogenes.

Authors:  Thomas Speiseder; Helga Hofmann-Sieber; Estefanía Rodríguez; Anna Schellenberg; Nuray Akyüz; Judith Dierlamm; Thilo Spruss; Claudia Lange; Thomas Dobner
Journal:  J Virol       Date:  2016-12-16       Impact factor: 5.103

2.  PML isoforms IV and V contribute to adenovirus-mediated oncogenic transformation by functionally inhibiting the tumor-suppressor p53.

Authors:  P Wimmer; J Berscheminski; P Blanchette; P Groitl; P E Branton; R T Hay; T Dobner; S Schreiner
Journal:  Oncogene       Date:  2015-03-16       Impact factor: 9.867

3.  Efficient and reproducible generation of high-expressing, stable human cell lines without need for antibiotic selection.

Authors:  Gudrun Schiedner; Sabine Hertel; Corinna Bialek; Helmut Kewes; Gero Waschütza; Christoph Volpers
Journal:  BMC Biotechnol       Date:  2008-02-12       Impact factor: 2.563
  3 in total

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