Effect of thaliblastine on transplantable tumours in mice.

The antitumour activity of the alkaloid thaliblastine was studied on 7 ascitic and solid transplantable tumours in mice. It was found that the compound has a pronounced antitumour effect on ascitic tumour of Ehrlich, NK/Ly lymphoma (i.p.), sarcoma 37 (s.c. and i.p.), sarcoma 180 (s.c.) and Lewis lung carcinoma (i.m.). With a number of tumours, it was found that the single and intermittent drug administration exerts a better therapeutic effect than the chronic treatment.