Literature DB >> 1369730

Wilms' tumour: reconciling genetics and biology.

V Van Heyningen1, N D Hastie.   

Abstract

Wilms' tumour, a paediatric malignancy of the kidney, is a striking example of the relationship between aberrant development and cancer. Several different genetic loci have been implicated in the aetiology of the tumour; genomic imprinting also plays a role. One Wilms' tumour predisposition gene (WT1), encoding a zinc finger protein, is expressed in a limited set of tissues, including developing nephrons and gonads. The biology and genetics of Wilms' tumour underline the developmental relationship between kidneys and gonads.

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Year:  1992        PMID： 1369730     DOI： 10.1016/0168-9525(92)90019-z

Source DB:  PubMed          Journal:  Trends Genet        ISSN： 0168-9525            Impact factor:   11.639


  19 in total

1.  The molecular basis of nephrogenesis and congenital kidney disease.

Authors:  J Bard
Journal:  Arch Dis Child       Date:  1992-08       Impact factor: 3.791

2.  The QM gene is X-linked and therefore not involved in suppression of tumorigenesis in Wilms' tumor.

Authors:  A M van den Ouweland; M Verdijk; M M Mannens; B A van Oost
Journal:  Hum Genet       Date:  1992 Sep-Oct       Impact factor: 4.132

Review 3.  Perspectives on zinc finger protein function and evolution--an update.

Authors:  T Pieler; E Bellefroid
Journal:  Mol Biol Rep       Date:  1994-07       Impact factor: 2.316

4.  Loss of heterozygosity at 11p13 and 11p15 in Wilms tumor: a study of 22 cases from India.

Authors:  Elanthenral Sigamani; Mohammad Nahidul Wari; Venkateswaran K Iyer; Sandeep Agarwala; Arundhati Sharma; Sameer Bakhshi; Amit Dinda
Journal:  Pediatr Surg Int       Date:  2013-01-05       Impact factor: 1.827

5.  Regulation of insulin-like growth factor I receptor gene expression by the Wilms' tumor suppressor WT1.

Authors:  H Werner; C T Roberts; F J Rauscher; D LeRoith
Journal:  J Mol Neurosci       Date:  1996       Impact factor: 3.444

6.  Expression and differential regulation of Id1, a dominant negative regulator of basic helix-loop-helix transcription factors, in glomerular mesangial cells.

Authors:  M S Simonson; A Rooney; W H Herman
Journal:  Nucleic Acids Res       Date:  1993-12-11       Impact factor: 16.971

7.  FISH studies in a patient with sporadic aniridia and t(7;11) (q31.2;p13).

Authors:  J A Crolla; I Cross; N Atkey; M Wright; C A Oley
Journal:  J Med Genet       Date:  1996-01       Impact factor: 6.318

8.  WNT5A is regulated by PAX2 and may be involved in blastemal predominant Wilms tumorigenesis.

Authors:  Yahya Tamimi; Usukuma Ekuere; Nicholas Laughton; Paul Grundy
Journal:  Neoplasia       Date:  2008-12       Impact factor: 5.715

9.  Increased expression of the insulin-like growth factor I receptor gene, IGF1R, in Wilms tumor is correlated with modulation of IGF1R promoter activity by the WT1 Wilms tumor gene product.

Authors:  H Werner; G G Re; I A Drummond; V P Sukhatme; F J Rauscher; D A Sens; A J Garvin; D LeRoith; C T Roberts
Journal:  Proc Natl Acad Sci U S A       Date:  1993-06-15       Impact factor: 11.205

Review 10.  Reflections on viruses and cancer.

Authors:  C Darcel
Journal:  Vet Res Commun       Date:  1994       Impact factor: 2.459
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