Literature DB >> 1369416

Viral proteases as targets for chemotherapeutic intervention.

C U Hellen1, E Wimmer.   

Abstract

Many viruses encode proteinases that are essential for infectivity, and are consequently attractive chemotherapeutic targets. The biochemistry and structure of the human immunodeficiency virus proteinase have been characterized extensively, and potent peptide-mimetic inhibitors have been developed. Techniques and strategies used to improve the efficiency of these compounds are likely to be applicable to other viral proteinases.

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Year:  1992        PMID： 1369416      PMCID： PMC7172713          DOI： 10.1016/0958-1669(92)90010-g

Source DB:  PubMed          Journal:  Curr Opin Biotechnol        ISSN： 0958-1669            Impact factor:   9.740


  39 in total

1.  Structure-based, C2 symmetric inhibitors of HIV protease.

Authors:  D J Kempf; D W Norbeck; L Codacovi; X C Wang; W E Kohlbrenner; N E Wideburg; D A Paul; M F Knigge; S Vasavanonda; A Craig-Kennard
Journal:  J Med Chem       Date:  1990-10       Impact factor: 7.446

2.  L-687,908, a potent hydroxyethylene-containing HIV protease inhibitor.

Authors:  J P Vacca; J P Guare; S J deSolms; W M Sanders; E A Giuliani; S D Young; P L Darke; J Zugay; I S Sigal; W A Schleif
Journal:  J Med Chem       Date:  1991-03       Impact factor: 7.446

3.  Characterization of poliovirus 2A proteinase by mutational analysis: residues required for autocatalytic activity are essential for induction of cleavage of eukaryotic initiation factor 4F polypeptide p220.

Authors:  C U Hellen; M Fäcke; H G Kräusslich; C K Lee; E Wimmer
Journal:  J Virol       Date:  1991-08       Impact factor: 5.103

4.  Role for the P4 amino acid residue in substrate utilization by the poliovirus 3CD proteinase.

Authors:  W S Blair; B L Semler
Journal:  J Virol       Date:  1991-11       Impact factor: 5.103

Review 5.  Proteolytic processing of polyproteins in the replication of RNA viruses.

Authors:  C U Hellen; H G Kräusslich; E Wimmer
Journal:  Biochemistry       Date:  1989-12-26       Impact factor: 3.162

6.  A series of potent HIV-1 protease inhibitors containing a hydroxyethyl secondary amine transition state isostere: synthesis, enzyme inhibition, and antiviral activity.

Authors:  T J Tucker; W C Lumma; L S Payne; J M Wai; S J de Solms; E A Giuliani; P L Darke; J C Heimbach; J A Zugay; W A Schleif
Journal:  J Med Chem       Date:  1992-07-10       Impact factor: 7.446

7.  Processing of in vitro-synthesized gag precursor proteins of human immunodeficiency virus (HIV) type 1 by HIV proteinase generated in Escherichia coli.

Authors:  H G Kräusslich; H Schneider; G Zybarth; C A Carter; E Wimmer
Journal:  J Virol       Date:  1988-11       Impact factor: 5.103

8.  Inhibitors of the protease from human immunodeficiency virus: design and modeling of a compound containing a dihydroxyethylene isostere insert with high binding affinity and effective antiviral activity.

Authors:  S Thaisrivongs; A G Tomasselli; J B Moon; J Hui; T J McQuade; S R Turner; J W Strohbach; W J Howe; W G Tarpley; R L Heinrikson
Journal:  J Med Chem       Date:  1991-08       Impact factor: 7.446

9.  Expression and characterization of recombinant hepatitis A virus 3C proteinase.

Authors:  B A Malcolm; S M Chin; D A Jewell; J R Stratton-Thomas; K B Thudium; R Ralston; S Rosenberg
Journal:  Biochemistry       Date:  1992-04-07       Impact factor: 3.162

10.  Structure at 2.5-A resolution of chemically synthesized human immunodeficiency virus type 1 protease complexed with a hydroxyethylene-based inhibitor.

Authors:  M Jaskólski; A G Tomasselli; T K Sawyer; D G Staples; R L Heinrikson; J Schneider; S B Kent; A Wlodawer
Journal:  Biochemistry       Date:  1991-02-12       Impact factor: 3.162
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  3 in total

1.  Inhibition of proteolytic activity of poliovirus and rhinovirus 2A proteinases by elastase-specific inhibitors.

Authors:  A Molla; C U Hellen; E Wimmer
Journal:  J Virol       Date:  1993-08       Impact factor: 5.103

2.  Viral cysteine proteinases.

Authors:  Alexander E Gorbalenya; Eric J Snijder
Journal:  Perspect Drug Discov Des       Date:  1996

Review 3.  Picornavirus inhibitors.

Authors:  L Carrasco
Journal:  Pharmacol Ther       Date:  1994       Impact factor: 12.310
  3 in total

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