Literature DB >> 13693271

The inactivation of enterovirus infectivity by the sulfhydryl reagent p-chloromercuribenzoate.

P W CHOPPIN, L PHILIPSON.   

Abstract

The infectivity of several enteroviruses was inactivated by the sulfhydryl reagent p-chloromercuribenzoate (PCMB). The rate of inactivation was dependent on the ionic environment in which the reaction was carried out. Inactivation of infectivity was reversed by the thiol compound, reduced glutathione. Under certain conditions, PCMB prevented the adsorption of some enteroviruses to monolayer cultures of monkey kidney cells. The results suggest that enterovirus sulfhydryl groups are involved in the establishment of infection, and that they play a role in the adsorption of virus to host cells.

Entities:  

Keywords:  BENZOATES/pharmacology; INDICATORS AND REAGENTS/pharmacology; VIRUSES/pharmacology

Mesh：

Substances：

Year:  1961        PMID： 13693271      PMCID： PMC2137380          DOI： 10.1084/jem.113.4.713

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  20 in total

1.  Virus particle adsorption, III. Adsorption of viruses by cell monolayers and effects of some variables on adsorption.

Authors:  A C ALLISON; R C VALENTINE
Journal:  Biochim Biophys Acta       Date:  1960-06-03

2.  Immunological characteristics of N.Y. strains of influenza A virus from the 1957 pandemic.

Authors:  P W CHOPPIN; S OSTERHOUT; I TAMM
Journal:  Proc Soc Exp Biol Med       Date:  1958-07

3.  Enhancement of influenza virus multiplication by 5-methyl-2-D-ribobenzimidazole.

Authors:  I TAMM
Journal:  Virology       Date:  1956-08       Impact factor: 3.616

4.  Relation of oxygen and temperature in the preservation of tissues by refrigeration.

Authors:  J H HANKS; R E WALLACE
Journal:  Proc Soc Exp Biol Med       Date:  1949-06

5.  The reversal in vivo by BAL of HgCI2-inactivated influenza A virus in the chick embryo.

Authors:  J E PEREZ; J BARALT-PEREZ; M KLEIN
Journal:  J Immunol       Date:  1949-08       Impact factor: 5.422

6.  Mammalian cell-virus relationship. III. Poliovirus production by non-primate cells exposed to poliovirus ribonucleic acid.

Authors:  J J HOLLAND; L C McLAREN; J T SYVERTON
Journal:  Proc Soc Exp Biol Med       Date:  1959-04

7.  The mammalian cell-virus relationship. I. Attachment of poliovirus to cultivated cells of primate and non-primate origin.

Authors:  L C McLAREN; J J HOLLAND; J T SYVERTON
Journal:  J Exp Med       Date:  1959-05-01       Impact factor: 14.307

8.  The mammalian cell-virus relationship. II. Adsorption, reception, and eclipse of poliovirus by HeLa cells.

Authors:  J J HOLLAND; L C McLAREN
Journal:  J Exp Med       Date:  1959-05-01       Impact factor: 14.307

9.  The mammalian cell-virus relationship. IV. Infection of naturally insusceptible cells with enterovirus ribonucleic acid.

Authors:  J J HOLLAND; L C McLAREN; J T SYVERTON
Journal:  J Exp Med       Date:  1959-07-01       Impact factor: 14.307

10.  THE MAMMALIAN CELL-VIRUS RELATIONSHIP : V. SUSCEPTIBILITY AND RESISTANCE OF CELLS IN VITRO TO INFECTION BY COXSACKIE A9 VIRUS.

Authors:  L C McLaren; J J Holland; J T Syverton
Journal:  J Exp Med       Date:  1960-09-30       Impact factor: 14.307
View more
  14 in total

1.  CYSTINE DEPENDENCE OF THERMORESISTANT MUTANTS OF POLIOVIRUS.

Authors:  C WALLIS; J L MELNICK
Journal:  J Bacteriol       Date:  1965-04       Impact factor: 3.490

2.  Effects of sulfhydryl inhibition on red blood cells. II. Studies in vivo.

Authors:  H S JACOB; J H JANDL
Journal:  J Clin Invest       Date:  1962-07       Impact factor: 14.808

3.  Specific inactivation of herpes simplex virus by silver nitrate at low concentrations and biological activities of the inactivated virus.

Authors:  F Shimizu; Y Shimizu; K Kumagai
Journal:  Antimicrob Agents Chemother       Date:  1976-07       Impact factor: 5.191

4.  Loss on serial passage of rhesus monkey kidney cells of proteolytic activity required for Sendai virus activation.

Authors:  S M Silver; A Scheid; P W Choppin
Journal:  Infect Immun       Date:  1978-04       Impact factor: 3.441

5.  Viral inactivation by disulfide bond reducing agents.

Authors:  D H Carver; D S Seto
Journal:  J Virol       Date:  1968-12       Impact factor: 5.103

6.  Isolation and properties of the helical nucleocapsid of the parainfluenza virus SV5.

Authors:  R W Compans; P W Choppin
Journal:  Proc Natl Acad Sci U S A       Date:  1967-04       Impact factor: 11.205

7.  The effect of mercurials on the integrity of the poliovirion.

Authors:  L Philipson
Journal:  Arch Gesamte Virusforsch       Date:  1965

8.  On the role of the response of the cell membrane in determining virus virulence. Contrasting effects of the parainfluenza virus SV5 in two cell types.

Authors:  K V Holmes; P W Choppin
Journal:  J Exp Med       Date:  1966-09-01       Impact factor: 14.307

9.  Effect of sulfhydryl reagents on the infectivity of vesicular stomatitis virus.

Authors:  S T Beatrice; R R Wagner
Journal:  Virology       Date:  1980-01-30       Impact factor: 3.616

10.  Distribution of cell receptors and simple sugar inhibitors during encephalomyocarditis virus-cell union.

Authors:  C M Kunin
Journal:  J Virol       Date:  1967-04       Impact factor: 5.103
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.