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Literature DB >> 13693090

A new biological method for the assay of depolarizing substances using the isolated semispinalis muscle of the chick.

Abstract

The isolated semispinalis cervicis muscle of a 3 to 10 days old chick has been found to provide a very useful assay method for depolarizing substances. There are three main advantages of this preparation over that of the rectus abdominis of the frog: (a) quick relaxation without any artificial stretching of the muscle, (b) greater sensitivity to depolarizing drugs, and (c) no falling off in sensitivity for at least 2 hr.

Entities: Species

Keywords: MUSCLES/pharmacology

Mesh：

Year: 1960 PMID： 13693090 PMCID： PMC1481847 DOI： 10.1111/j.1476-5381.1960.tb01265.x

Source DB: PubMed Journal: Br J Pharmacol Chemother ISSN： 0366-0826

2 in total

1. The interruption of neuromuscular transmission and some of its problems.

Authors: E J ZAIMIS
Journal: Pharmacol Rev Date: 1954-03 Impact factor: 25.468

2. A method of conducting a biological assay on a preparation giving repeated graded responses illustrated by the estimation of histamine.

Authors: H O Schild
Journal: J Physiol Date: 1942-06-02 Impact factor: 5.182

2 in total

11 in total

1. A note on the isolated nerve sternotrachealis preparation of the chicken.

Authors: R F CARLYLE
Journal: Br J Pharmacol Chemother Date: 1962-06

2. Neuromuscular blocking activities of some steroidal mono and bis-quaternary ammonium compounds with special reference to NN'-dimethylconessine.

Authors: D Busfield; K J Child; A J Clarke; B Davis; M G Dodds
Journal: Br J Pharmacol Chemother Date: 1968-03

A new biological method for the assay of depolarizing substances using the isolated semispinalis muscle of the chick.

1. The interruption of neuromuscular transmission and some of its problems.

2. A method of conducting a biological assay on a preparation giving repeated graded responses illustrated by the estimation of histamine.

1. A note on the isolated nerve sternotrachealis preparation of the chicken.

2. Neuromuscular blocking activities of some steroidal mono and bis-quaternary ammonium compounds with special reference to NN'-dimethylconessine.

3. Effects of quinuronium methylsulphate on voluntary muscle.

4. The synthesis and pharmacology of some 1,4,5,6-tetrahydropyrimidines.

5. Pharmacology of some acetylcholine homologues.

6. The neuromuscular blocking action of a series of bicyclic bis-oniu esters.

7. Aspects of the pharmacology of a new anthelmintic: pyrantel.

8. Nicotinic stimulant action of some tolyl and xylyl analogues of 1,1-dimethyl-4-phenylpiperazinium (DMPP).

9. Structure-activity relationships in some series of 2-alkyl-1,2,3,-benzotriazinium compounds.

10. THE RESPONSE OF THE ISOLATED SKIN OF RATS TO DRUGS AND ELECTRICAL STIMULATION.