Literature DB >> 1369070

Isolation and synthesis of a new bio-antimutagen, petasiphenol, from scapes of Petasites japonicum.

R Iriye1, K Furukawa, R Nishida, C Kim, H Fukami.   

Abstract

A new bio-antimutagen, petasiphenol [3-(3,4-dihydroxyphenyl)-2-oxopropyl caffeate] (1) was isolated from scapes of Petasites japonicum (AD50 = 95 micrograms/ml against UV-induced mutagenic E. coli WP2 B/r Trp-. Petasiphenol (1) and its isomer (2) were synthesized. The activity of 1 was observed in the presence of soybean oil (glyceride), although the isomer (2) did not show any activity in doses up to 300 micrograms/ml.

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Year:  1992        PMID： 1369070     DOI： 10.1271/bbb.56.1773

Source DB:  PubMed          Journal:  Biosci Biotechnol Biochem        ISSN： 0916-8451            Impact factor:   2.043


  3 in total

1.  Neuroprotection by extract of Petasites japonicus leaves, a traditional vegetable, against oxidative stress in brain of mice challenged with kainic acid.

Authors:  D-E Sok; S H Oh; Y-B Kim; H-G Kang; M R Kim
Journal:  Eur J Nutr       Date:  2005-07-07       Impact factor: 5.614

2.  Antiproliferative effect of the methanol extract from the roots of Petasites japonicus on Hep3B hepatocellular carcinoma cells in vitro and in vivo.

Authors:  Hyun Jung Kim; Song Yi Park; Hye Min Lee; Dong Ik Seo; Young-Min Kim
Journal:  Exp Ther Med       Date:  2015-02-17       Impact factor: 2.447

3.  Antimutagenic and anticarcinogenic effect of methanol extracts of Petasites japonicus Maxim leaves.

Authors:  Hwan-Goo Kang; Sang-Hee Jeong; Joon-Hyoung Cho
Journal:  J Vet Sci       Date:  2010-03       Impact factor: 1.672
  3 in total

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