Literature DB >> 13689559

The effect of hexamethonium on the carotid chemoreceptor response to nicotine and cyanide.

R BYCK.   

Abstract

The literature concerning the effects of ganglionic blocking agents on the chemoreceptors is reviewed. Hexamethonium blocks the respiratory response to intracarotid injections of small doses of nicotine in dogs anaesthetized with chloralose, but it does not block the response to sodium cyanide.

Entities:  

Keywords:  CAROTID BODY/pharmacology; CYANIDES/pharmacology; HEXAMETHONIUM COMPOUNDS/pharmacology; NICOTINE/pharmacology

Mesh：

Substances：

Year:  1961        PMID： 13689559      PMCID： PMC1482015          DOI： 10.1111/j.1476-5381.1961.tb00293.x

Source DB:  PubMed          Journal:  Br J Pharmacol Chemother        ISSN： 0366-0826


  7 in total

1.  Effects of stimulants and of ganglionic blocking agents on carotid chemoreceptors.

Authors:  A S DONTAS; M NICKERSON
Journal:  Arch Int Pharmacodyn Ther       Date:  1956-05-01

2.  The effect of certain autonomic drugs on the chemoreceptors of the carotid body and the baroreceptors of the carotid sinus.

Authors:  C HEYMANS; A L DELAUNOIS; L MARTINI; P JANSSEN
Journal:  Arch Int Pharmacodyn Ther       Date:  1953-11-01

3.  The effect of certain autonomic drugs on the action potentials of the sinus nerve.

Authors:  S LANDGREN; G LILJESTRAND; Y ZOTTERMAN
Journal:  Acta Physiol Scand       Date:  1952-09-10

4.  The influence of the sympathetic innervation of the carotid bifurcation on chemoceptor and baroceptor activity in the cat.

Authors:  W F FLOYD; E NEIL
Journal:  Arch Int Pharmacodyn Ther       Date:  1952-09-01

5.  The effect of a ganglion-blocking drug, hexamethonium, on the response of the cat's carotid body to various stimuli.

Authors:  W W DOUGLAS
Journal:  J Physiol       Date:  1952-11       Impact factor: 5.182

6.  Volume of distribution of hexamethonium in nephrectomized dogs.

Authors:  C MONGE; A C CORCORAN; F DEL GRECO; I H PAGE
Journal:  Am J Physiol       Date:  1954-08

7.  [The effect of bisquaternary ammonium salts on the carotid body of the cat].

Authors:  K GOLLWITZER-MEIER; E WITZLEB
Journal:  Pflugers Arch Gesamte Physiol Menschen Tiere       Date:  1953
  7 in total
  7 in total

1.  Rapid sensitization of physiological, neuronal, and locomotor effects of nicotine: critical role of peripheral drug actions.

Authors:  Magalie Lenoir; Jeremy S Tang; Amina S Woods; Eugene A Kiyatkin
Journal:  J Neurosci       Date:  2013-06-12       Impact factor: 6.167

2.  Effects of cyanide and doxapram during panting.

Authors:  A V Ruiz
Journal:  Pflugers Arch       Date:  1975-12-19       Impact factor: 3.657

3.  Effects of cyanide and doxapram during hypothermia.

Authors:  A V Ruiz
Journal:  Pflugers Arch       Date:  1975-12-19       Impact factor: 3.657

4.  Stimulation of the carotid chemoreceptors of the dog by dopamine.

Authors:  L Jacobs; J H Comroe
Journal:  Proc Natl Acad Sci U S A       Date:  1968-04       Impact factor: 11.205

5.  Critical role of peripheral actions of intravenous nicotine in mediating its central effects.

Authors:  Magalie Lenoir; Eugene A Kiyatkin
Journal:  Neuropsychopharmacology       Date:  2011-06-08       Impact factor: 7.853

6.  A quantitative study of the effects of cholinergic drugs on carotid chemoreceptors in the cat.

Authors:  D S McQueen
Journal:  J Physiol       Date:  1977-12       Impact factor: 5.182

7.  Effects of mecamylamine on responses of carotid body chemoreceptors in vivo to physiological and pharmacological stimuli.

Authors:  S R Sampson
Journal:  J Physiol       Date:  1971-02       Impact factor: 5.182
  7 in total

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