Literature DB >> 1368876

Deamidation: a source of microheterogeneity in pharmaceutical proteins.

D T Liu1.   

Abstract

Most protein molecules undergo some degree of spontaneous deamidation in vivo. This process may also occur during the production, isolation, purification, formulation and storage of pharmaceutical proteins. Deamidation is a potential source of microheterogeneity for pharmaceutical proteins, and this is an important issue that needs to be addressed, not only by the manufacturers but also by the national control agencies. This article provides an overview of the scientific and regulatory issues pertinent to deamidation of pharmaceutical proteins.

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Year:  1992        PMID： 1368876     DOI： 10.1016/0167-7799(92)90269-2

Source DB:  PubMed          Journal:  Trends Biotechnol        ISSN： 0167-7799            Impact factor:   19.536


  12 in total

1.  Selective cleavage of isoaspartyl peptide bonds by hydroxylamine after methyltransferase priming.

Authors:  Jeff X Zhu; Dana W Aswad
Journal:  Anal Biochem       Date:  2007-02-22       Impact factor: 3.365

2.  A density functional theory study on peptide bond cleavage at aspartic residues: direct vs cyclic intermediate hydrolysis.

Authors:  Wichien Sang-aroon; Vittaya Amornkitbamrung; Vithaya Ruangpornvisuti
Journal:  J Mol Model       Date:  2013-11-17       Impact factor: 1.810

3.  Elucidation of degradants in acidic peak of cation exchange chromatography in an IgG1 monoclonal antibody formed on long-term storage in a liquid formulation.

Authors:  Sejal Gandhi; Da Ren; Gang Xiao; Pavel Bondarenko; Christopher Sloey; Margaret Speed Ricci; Sampathkumar Krishnan
Journal:  Pharm Res       Date:  2011-08-16       Impact factor: 4.200

4.  Top-down study of β2-microglobulin deamidation.

Authors:  Xiaojuan Li; Xiang Yu; Catherine E Costello; Cheng Lin; Peter B O'Connor
Journal:  Anal Chem       Date:  2012-06-29       Impact factor: 6.986

5.  Narbonin, a novel 2S protein from Vicia narbonensis L. seeds: cDNA, gene structure and developmentally regulated formation.

Authors:  V H Nong; B Schlesier; R Bassüner; A Repik; C Horstmann; K Müntz
Journal:  Plant Mol Biol       Date:  1995-04       Impact factor: 4.076

6.  The Separation and Quantitation of Peptides with and without Oxidation of Methionine and Deamidation of Asparagine Using Hydrophilic Interaction Liquid Chromatography with Mass Spectrometry (HILIC-MS).

Authors:  Majors J Badgett; Barry Boyes; Ron Orlando
Journal:  J Am Soc Mass Spectrom       Date:  2017-01-03       Impact factor: 3.109

7.  Effect of N-1 and N-2 residues on peptide deamidation rate in solution and solid state.

Authors:  Bei Li; Richard L Schowen; Elizabeth M Topp; Ronald T Borchardt
Journal:  AAPS J       Date:  2006-03-20       Impact factor: 4.009

8.  Characterization of asparagine deamidation and aspartate isomerization in recombinant human interleukin-11.

Authors:  Wei Zhang; J Marta J Czupryn; Philip T Boyle; John Amari
Journal:  Pharm Res       Date:  2002-08       Impact factor: 4.200

9.  Distinct patterns of expression but similar biochemical properties of protein L-isoaspartyl methyltransferase in higher plants.

Authors:  N Thapar; A K Kim; S Clarke
Journal:  Plant Physiol       Date:  2001-02       Impact factor: 8.340

10.  Structural Characterisation of Non-Deamidated Acidic Variants of Erwinia chrysanthemi L-asparaginase Using Small-Angle X-ray Scattering and Ion-Mobility Mass Spectrometry.

Authors:  David Gervais; Darryl King; Patrick Kanda; Nicholas Foote; Lucy Elliott; Phillip Brown; Natacha O Lee; Konstantinos Thalassinos; Claire Pizzey; Robert Rambo; Thomas C Minshull; Mark J Dickman; Stuart Smith
Journal:  Pharm Res       Date:  2015-06-04       Impact factor: 4.200
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