Literature DB >> 1368725

Commercial levels of chymosin production by Aspergillus.

N S Dunn-Coleman1, P Bloebaum, R M Berka, E Bodie, N Robinson, G Armstrong, M Ward, M Przetak, G L Carter, R LaCost.   

Abstract

We have increased the production of bovine chymosin in Aspergillus niger var. awamori to more than one gram per liter of secreted authentic enzyme by combining a mutagenesis protocol with a novel robotic screening program. Analysis of the superior chymosin producing strains indicated that they have enhanced capabilities to secrete extracellular proteins.

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Year:  1991        PMID： 1368725     DOI： 10.1038/nbt1091-976

Source DB:  PubMed          Journal:  Biotechnology (N Y)        ISSN： 0733-222X


  24 in total

Review 1.  Filamentous fungi as production organisms for glycoproteins of bio-medical interest.

Authors:  M Maras; I van Die; R Contreras; C A van den Hondel
Journal:  Glycoconj J       Date:  1999-02       Impact factor: 2.916

2.  Shotgun proteomics of Aspergillus niger microsomes upon D-xylose induction.

Authors:  José Miguel P Ferreira de Oliveira; Mark W J van Passel; Peter J Schaap; Leo H de Graaff
Journal:  Appl Environ Microbiol       Date:  2010-05-07       Impact factor: 4.792

Review 3.  Contributions of microorganisms to industrial biology.

Authors:  Arnold L Demain; Jose L Adrio
Journal:  Mol Biotechnol       Date:  2008-01       Impact factor: 2.695

4.  Use of laccase as a novel, versatile reporter system in filamentous fungi.

Authors:  Gerd J Mander; Huaming Wang; Elizabeth Bodie; Jens Wagner; Kay Vienken; Claudia Vinuesa; Caroline Foster; Abigail C Leeder; Gethin Allen; Valerie Hamill; Giselle G Janssen; Nigel Dunn-Coleman; Marvin Karos; Hans Georg Lemaire; Thomas Subkowski; Claus Bollschweiler; Geoffrey Turner; Bernhard Nüsslein; Reinhard Fischer
Journal:  Appl Environ Microbiol       Date:  2006-07       Impact factor: 4.792

5.  Production of Trichoderma reesei cellulases on glucose-containing media.

Authors:  T Nakari-Setälä; M Penttilä
Journal:  Appl Environ Microbiol       Date:  1995-10       Impact factor: 4.792

6.  Analysis of heterologous protein production in defined recombinant Aspergillus awamori strains.

Authors:  R J Gouka; P J Punt; J G Hessing; C A van den Hondel
Journal:  Appl Environ Microbiol       Date:  1996-06       Impact factor: 4.792

7.  A new black Aspergillus species, A. vadensis, is a promising host for homologous and heterologous protein production.

Authors:  Ronald P de Vries; Kim Burgers; Peter J I van de Vondervoort; Jens C Frisvad; Robert A Samson; Jaap Visser
Journal:  Appl Environ Microbiol       Date:  2004-07       Impact factor: 4.792

8.  Improvement of foreign-protein production in Aspergillus niger var. awamori by constitutive induction of the unfolded-protein response.

Authors:  Mari Valkonen; Michael Ward; Huaming Wang; Merja Penttilä; Markku Saloheimo
Journal:  Appl Environ Microbiol       Date:  2003-12       Impact factor: 4.792

9.  Influence of culture conditions on the production of milk-clotting enzyme from Rhizomucor.

Authors:  S Preetha; R Boopathy
Journal:  World J Microbiol Biotechnol       Date:  1994-09       Impact factor: 3.312

10.  Codon optimization increases steady-state mRNA levels in Aspergillus oryzae heterologous gene expression.

Authors:  Masafumi Tokuoka; Mizuki Tanaka; Kazuhisa Ono; Shinobu Takagi; Takahiro Shintani; Katsuya Gomi
Journal:  Appl Environ Microbiol       Date:  2008-09-12       Impact factor: 4.792
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