Literature DB >> 13685339

Enzymatic formation of psychotomimetic metabolites from normally occurring compounds.

J AXELROD.   

Abstract

An enzyme has been found that N-methylates serotonin and tryptamine to psychotomimetic metabolites, bufotenine and N,N-dimethyltryptamine. This enzyme is highly localized in the rabbit lung and also N-methylates phenylethylamine derivatives such as tyramine, phenylethylamine , mescaline, and dopamine.

Entities:  

Keywords:  HALLUCINOGENS/metabolism; INDOLES/metabolism; SEROTONIN/metabolism

Mesh：

Substances：

Year:  1961        PMID： 13685339     DOI： 10.1126/science.134.3475.343

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  21 in total

1.  Biochemistry of schizophrenia.

Authors:  J R SMYTHIES
Journal:  Postgrad Med J       Date:  1963-01       Impact factor: 2.401

2.  Excretion of catecholamines and tryptophan derivatives in schizophrenia.

Authors:  Y A Mileikovskii
Journal:  Neurosci Behav Physiol       Date:  1979 Oct-Dec

Review 3.  On the physiology of metazoa.

Authors:  A R Ameen
Journal:  Experientia       Date:  1996-03-15

4.  Stimulus properties of mescaline and N-methylated derivatives: difference in peripheral and direct central administration.

Authors:  R G Browne; R T Harris; B T Ho
Journal:  Psychopharmacologia       Date:  1974

5.  [Quantitative determination of an increased excretion of bufotenin in urine of schizophrenics].

Authors:  E Fischer; H Spatz
Journal:  Arch Psychiatr Nervenkr (1970)       Date:  1968

6.  [Studies on the excretion of catecholamines and their degradation products in hypertension and pheochromocytoma].

Authors:  R Clotten; J Michaelis
Journal:  Klin Wochenschr       Date:  1966-10-15

Review 7.  A possibly sigma-1 receptor mediated role of dimethyltryptamine in tissue protection, regeneration, and immunity.

Authors:  Ede Frecska; Attila Szabo; Michael J Winkelman; Luis E Luna; Dennis J McKenna
Journal:  J Neural Transm (Vienna)       Date:  2013-04-26       Impact factor: 3.575

8.  The hallucinogen N,N-dimethyltryptamine (DMT) is an endogenous sigma-1 receptor regulator.

Authors:  Dominique Fontanilla; Molly Johannessen; Abdol R Hajipour; Nicholas V Cozzi; Meyer B Jackson; Arnold E Ruoho
Journal:  Science       Date:  2009-02-13       Impact factor: 47.728

Review 9.  When the endogenous hallucinogenic trace amine N,N-dimethyltryptamine meets the sigma-1 receptor.

Authors:  Tsung-Ping Su; Teruo Hayashi; D Bruce Vaupel
Journal:  Sci Signal       Date:  2009-03-10       Impact factor: 8.192

10.  Dimethyltryptamine and other hallucinogenic tryptamines exhibit substrate behavior at the serotonin uptake transporter and the vesicle monoamine transporter.

Authors:  Nicholas V Cozzi; Anupama Gopalakrishnan; Lyndsey L Anderson; Joel T Feih; Alexander T Shulgin; Paul F Daley; Arnold E Ruoho
Journal:  J Neural Transm (Vienna)       Date:  2009-09-12       Impact factor: 3.575
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