Literature DB >> 13680536

Cyclosporine nephrotoxicity.

Emmanuel A Burdmann1, Takeshi F Andoh, Luis Yu, William M Bennett.   

Abstract

After more than 20 years of cyclosporine use its nephrotoxicity remains a significant clinical problem. Cyclosporine-induced renal injury has been described in solid organs recipients and in patients treated for autoimmune diseases. It is manifested in 2 distinct and well characterized forms, acute nephrotoxicity and chronic nephrotoxicity. This communication reviews the current literature analyzing the available data about the pathogenesis and mechanisms of acute and chronic cyclosporine-induced nephrotoxicity. A working hypothesis for the possible mechanisms of chronic cyclosporine nephrotoxicity will be provided.

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Year:  2003        PMID： 13680536     DOI： 10.1016/s0270-9295(03)00090-1

Source DB:  PubMed          Journal:  Semin Nephrol        ISSN： 0270-9295            Impact factor:   5.299


  43 in total

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Review 5.  Renal dysfunction following bone marrow transplantation.

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7.  Isolated hyperkalemia associated with cyclosporine administration in allogeneic stem cell transplantation for renal cell carcinoma.

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9.  Donor age and renal P-glycoprotein expression associate with chronic histological damage in renal allografts.

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10.  Sex differences in response to cyclosporine immunosuppression in experimental kidney transplantation.

Authors:  Veronika Muller; Attila J Szabo; Aaron Erdely; You-Lin Tain; Chris Baylis
Journal:  Clin Exp Pharmacol Physiol       Date:  2007-12-07       Impact factor: 2.557
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