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Literature DB >> 13680325

Vaccination of autologous stem cell transplant recipients with live varicella vaccine: a pilot study.

P Ljungman¹, F Z Wang, C Nilsson, V Solheim, A Linde.

Abstract

A pilot study of vaccination with live, attenuated varicella vaccine for prevention of zoster was performed in autologous stem cell transplant (SCT) recipients. Nine patients were vaccinated between 3-4 months after transplantation. The antigen-specific immune response was studied by lymphocyte proliferation. No systemic side effects were seen. One of nine patients developed herpes zoster HZ during follow-up. There was a tendency for a strengthened specific immune response after SCT ( p=0.12). This pilot study shows that vaccination with live, attenuated varicella vaccine can be performed safely 3-4 months after autologous stem cell transplantation. Additional studies are needed to assess efficacy of this approach in the prevention of HZ.

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Year: 2003 PMID： 13680325 DOI： 10.1007/s00520-003-0527-8

Source DB: PubMed Journal: Support Care Cancer ISSN： 0941-4355 Impact factor: 3.603

8 in total

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Authors: Atsuko Hata; Hideomi Asanuma; Mary Rinki; Margaret Sharp; Ruby M Wong; Karl Blume; Ann M Arvin
Journal: N Engl J Med Date: 2002-07-04 Impact factor: 91.245

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Journal: Biken J Date: 1975-03

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Journal: Blood Date: 1989-09 Impact factor: 22.113

4. Early reconstitution of immunity and decreased severity of herpes zoster in bone marrow transplant recipients immunized with inactivated varicella vaccine.

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Journal: J Infect Dis Date: 1997-09 Impact factor: 5.226

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Journal: J Infect Dis Date: 1986-05 Impact factor: 5.226

6. Efficacy and safety of vaccination of marrow transplant recipients with a live attenuated measles, mumps, and rubella vaccine.

Authors: P Ljungman; E Fridell; B Lönnqvist; P Bolme; M Böttiger; G Gahrton; A Linde; O Ringdén; B Wahren
Journal: J Infect Dis Date: 1989-04 Impact factor: 5.226

7. Varicella-zoster virus infections after autologous bone marrow transplantation in children.

Authors: P Wacker; O Hartmann; E Benhamou; E Salloum; J Lemerle
Journal: Bone Marrow Transplant Date: 1989-03 Impact factor: 5.483

8. The prophylactic role of intravenous and long-term oral acyclovir after allogeneic bone marrow transplantation.

Authors: P J Selby; R L Powles; D Easton; T J Perren; K Stolle; B Jameson; A P Fiddian; Y Tryhorn; H Stern
Journal: Br J Cancer Date: 1989-03 Impact factor: 7.640