Classical conditioning and modification of the rabbit's (Oryctolagus cuniculus) unconditioned nictitating membrane response.

A fundamental tenet of behavior is that a reflex is automatic, unconscious, involuntary, and relatively invariant. However, we have discovered that a reflex can change dramatically as a function of classical conditioning, and this change can be demonstrated independently of the conditioned stimulus. We have termed this phenomenon conditioning-specific reflex modification (CRM). Although the behavioral laws and neural substrates of nonassociative reflex changes have been identified, the behavioral laws and neural substrates of CRM are only now being revealed. For example, CRM is similar to classical conditioning in that (a) it is a function of both the strength of conditioning and (b) the strength of the unconditioned stimulus, (c) it can be extinguished, and (d) it can be generalized from one unconditioned stimulus to another. Preliminary analysis suggests that CRM may have some features in common with post-traumatic stress disorder and may provide insights into treatment of the disorder.