Literature DB >> 1367846

Bispecific antibodies for targeted cellular cytotoxicity.

M W Fanger1, P M Guyre.   

Abstract

Bispecific antibodies have the ability to redirect normal cytotoxic mechanisms to kill tumors or pathogens and thus represent a potentially powerful tool for the therapy of cancer and infectious disease.

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Year:  1991        PMID： 1367846     DOI： 10.1016/0167-7799(91)90129-6

Source DB:  PubMed          Journal:  Trends Biotechnol        ISSN： 0167-7799            Impact factor:   19.536


  3 in total

Review 1.  The biotechnology and applications of antibody engineering.

Authors:  R Rapley
Journal:  Mol Biotechnol       Date:  1995-04       Impact factor: 2.695

2.  Human single-chain Fv immunoconjugates targeted to a melanoma-associated chondroitin sulfate proteoglycan mediate specific lysis of human melanoma cells by natural killer cells and complement.

Authors:  B Wang; Y B Chen; O Ayalon; J Bender; A Garen
Journal:  Proc Natl Acad Sci U S A       Date:  1999-02-16       Impact factor: 11.205

3.  Unprimed CD4+ and CD8+ T cells can be rapidly activated by a CD3 x CD19 bispecific antibody to proliferate and become cytotoxic.

Authors:  I A Haagen; W B de Lau; B J Bast; A J Geerars; M R Clark; B C de Gast
Journal:  Cancer Immunol Immunother       Date:  1994-12       Impact factor: 6.968
  3 in total

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