Literature DB >> 1367768

The oligosaccharides of glycoproteins: bioprocess factors affecting oligosaccharide structure and their effect on glycoprotein properties.

C F Goochee1, M J Gramer, D C Andersen, J B Bahr, J R Rasmussen.   

Abstract

In this review, we organize the recent data concerning the effects of bioprocess factors on the oligosaccharide structure of human therapeutic glycoproteins, with particular emphasis on the influence of the host cell. We also discuss the effect of oligosaccharide structure on glycoprotein properties, including antigenicity, immunogenicity and plasma clearance rate.

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Year:  1991        PMID： 1367768     DOI： 10.1038/nbt1291-1347

Source DB:  PubMed          Journal:  Biotechnology (N Y)        ISSN： 0733-222X


  42 in total

1.  Building high affinity human antibodies by altering the glycosylation on the light chain variable region in N-acetylglucosamine-supplemented hybridoma cultures.

Authors:  H Tachibana; J Y Kim; S Shirahata
Journal:  Cytotechnology       Date:  1997-01       Impact factor: 2.058

2.  Genetic engineering of α2,6-sialyltransferase in recombinant CHO cells and its effects on the sialylation of recombinant interferon-γ.

Authors:  L Monaco; A Marc; A Eon-Duval; G Acerbis; G Distefano; D Lamotte; J M Engasser; M Soria; N Jenkins
Journal:  Cytotechnology       Date:  1996-01       Impact factor: 2.058

3.  Optimization of the medium perfusion rate in a packed-bed bioreactor charged with CHO cells.

Authors:  F Meuwly; U von Stockar; A Kadouri
Journal:  Cytotechnology       Date:  2005-06-16       Impact factor: 2.058

4.  A lectin method for investigating the glycosylation of nanogram amounts of purified glycoprotein.

Authors:  M T Goodarzi; G A Turner
Journal:  Glycoconj J       Date:  1997-06       Impact factor: 2.916

5.  The K1K2 region of Lys-gingipain of Porphyromonas gingivalis blocks induction of HLA expression by gamma interferon.

Authors:  Peter L Yun; Nan Li; Charles A Collyer; Neil Hunter
Journal:  Infect Immun       Date:  2012-07-16       Impact factor: 3.441

6.  Selective identification and differentiation of N- and O-linked oligosaccharides in glycoproteins by liquid chromatography-mass spectrometry.

Authors:  S A Carr; M J Huddleston; M F Bean
Journal:  Protein Sci       Date:  1993-02       Impact factor: 6.725

7.  Cloning and expression of human sialic acid pathway genes to generate CMP-sialic acids in insect cells.

Authors:  S M Lawrence; K A Huddleston; N Tomiya; N Nguyen; Y C Lee; W F Vann; T A Coleman; M J Betenbaugh
Journal:  Glycoconj J       Date:  2001-03       Impact factor: 2.916

8.  Streptomyces lividans glycosylates the linker region of a beta-1,4-glycanase from Cellulomonas fimi.

Authors:  E Ong; D G Kilburn; R C Miller; R A Warren
Journal:  J Bacteriol       Date:  1994-02       Impact factor: 3.490

9.  Enhancement of human prolactin synthesis by sodium butyrate addition to serum-free CHO cell culture.

Authors:  Herbert Rodrigues Goulart; Fernanda dos Santos Arthuso; Marcos Vinicius Nucci Capone; Taís Lima de Oliveira; Paolo Bartolini; Carlos Roberto Jorge Soares
Journal:  J Biomed Biotechnol       Date:  2010-06-16

10.  Isolation of a mutant Arabidopsis plant that lacks N-acetyl glucosaminyl transferase I and is unable to synthesize Golgi-modified complex N-linked glycans.

Authors:  A von Schaewen; A Sturm; J O'Neill; M J Chrispeels
Journal:  Plant Physiol       Date:  1993-08       Impact factor: 8.340
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