Literature DB >> 1367682

CD4: its structure, role in immune function and AIDS pathogenesis, and potential as a pharmacological target.

R W Sweet1, A Truneh, W A Hendrickson.   

Abstract

CD4 is critical for the development and function of the CD4+ subset of T cells and also subserves as the receptor for the human immunodeficiency viruses. Reports in the past year clarify the role and the molecular interactions of CD4 in these events. Determination of the structure of an extracellular fragment of CD4 reveals novel variations of the immunoglobulin fold and provides an atomic framework for interpretation of its interactions with MHC class II molecules and with gp120, the external envelope glycoprotein of the human immunodeficiency virus.

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Year:  1991        PMID： 1367682     DOI： 10.1016/0958-1669(91)90089-n

Source DB:  PubMed          Journal:  Curr Opin Biotechnol        ISSN： 0958-1669            Impact factor:   9.740


  16 in total

1.  Rational engineering of a miniprotein that reproduces the core of the CD4 site interacting with HIV-1 envelope glycoprotein.

Authors:  C Vita; E Drakopoulou; J Vizzavona; S Rochette; L Martin; A Ménez; C Roumestand; Y S Yang; L Ylisastigui; A Benjouad; J C Gluckman
Journal:  Proc Natl Acad Sci U S A       Date:  1999-11-09       Impact factor: 11.205

2.  Human immunodeficiency virus type 1 attachment to HeLa CD4 cells is CD4 independent and gp120 dependent and requires cell surface heparans.

Authors:  I Mondor; S Ugolini; Q J Sattentau
Journal:  J Virol       Date:  1998-05       Impact factor: 5.103

3.  Successful immunomodulating in AIDS patients with ursodeoxycholic acid--a pilot study.

Authors:  D Kurktschiev; T Temelkova-Kurktschiev; K Horn; K Schentke
Journal:  Clin Exp Immunol       Date:  1999-01       Impact factor: 4.330

4.  Cell and viral regulatory elements enhance the expression and function of a human immunodeficiency virus inhibitory gene.

Authors:  U Ranga; C Woffendin; Z Y Yang; L Xu; S Verma; D R Littman; G J Nabel
Journal:  J Virol       Date:  1997-09       Impact factor: 5.103

5.  Disulfide reduction in CD4 domain 1 or 2 is essential for interaction with HIV glycoprotein 120 (gp120), which impairs thioredoxin-driven CD4 dimerization.

Authors:  Nichole Cerutti; Mark Killick; Vinesh Jugnarain; Maria Papathanasopoulos; Alexio Capovilla
Journal:  J Biol Chem       Date:  2014-02-18       Impact factor: 5.157

6.  A monoclonal antibody to the CDR-3 region of CD4 inhibits soluble CD4 binding to virions of human immunodeficiency virus type 1.

Authors:  J P Moore
Journal:  J Virol       Date:  1993-06       Impact factor: 5.103

Review 7.  Pathogenesis of human immunodeficiency virus infection.

Authors:  J A Levy
Journal:  Microbiol Rev       Date:  1993-03

8.  Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody.

Authors:  P D Kwong; R Wyatt; J Robinson; R W Sweet; J Sodroski; W A Hendrickson
Journal:  Nature       Date:  1998-06-18       Impact factor: 49.962

9.  Proteinase-resistant factors in human erythrocyte membranes mediate CD4-dependent fusion with cells expressing human immunodeficiency virus type 1 envelope glycoproteins.

Authors:  T Dragic; L Picard; M Alizon
Journal:  J Virol       Date:  1995-02       Impact factor: 5.103

10.  Factors involved in entry of the human immunodeficiency virus type 1 into permissive cells: lack of evidence of a role for CD26.

Authors:  I Lazaro; D Naniche; N Signoret; A M Bernard; D Marguet; D Klatzmann; T Dragic; M Alizon; Q Sattentau
Journal:  J Virol       Date:  1994-10       Impact factor: 5.103
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