Literature DB >> 13675772

Inhibition of O-methyltransferase by catechol and sensitization to epinephrine.

Z M BACQ, L GOSSELIN, A DRESSE, J RENSON.   

Abstract

Catechol at equimolecular concentration inhibits the inactivation of adrenaline by O-methyltransferase in vitro about 50 percent. The inhibition is probably responsible for the sensitization of smooth muscles to epinephrine by various ortho di- or triphenols.

Entities:  

Keywords:  EPINEPHRINE/physiology; PYROCATECHOL/effects; TRANSFERASES

Mesh：

Substances：

Year:  1959        PMID： 13675772     DOI： 10.1126/science.130.3373.453

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  6 in total

1.  [BIOCHEMICAL STUDIES ON HYPERSENSITIVITY TO SYMPATHOMIMETICS FOLLOWING THYROXIN ADMINISTRATION].

Authors:  H J DENGLER
Journal:  Acta Neuroveg (Wien)       Date:  1964-10-02

2.  Metabolism of 7-H3-epinephrine-d-bitartrate in normal young men.

Authors:  E H LABROSSE; J AXELROD; I J KOPIN; S S KETY
Journal:  J Clin Invest       Date:  1961-02       Impact factor: 14.808

3.  Effects of cocaine and of monoamine oxidase and catechol-o-methyl transferase inhibitors on transmission to the guinea-pig vas deferens.

Authors:  C Bell
Journal:  Br J Pharmacol Chemother       Date:  1967-10

4.  Effects of catechol on human subjects: a field survey.

Authors:  I Hirosawa; G Asaeda; H Arizono; S Shimbo; M Ikeda
Journal:  Int Arch Occup Environ Health       Date:  1976-06-03       Impact factor: 3.015

5.  Relation between the amount of smooth muscle of venous tissue and the degree of supersensitivity to isoprenaline caused by inhibition of catechol-O-methyl transferase.

Authors:  S Guimarães; I Azevedo; W Cardoso; M C Oliveira
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1975       Impact factor: 3.000

6.  A pharmacological study of the spontaneous convulsive activity induced by 1,2-dihydroxybenzene (catechol) in the anaesthetized mouse.

Authors:  A Angel; K A Clarke; D G Dewhurst
Journal:  Br J Pharmacol       Date:  1977-11       Impact factor: 8.739
  6 in total

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