Literature DB >> 13673135

The effect of antigenic stimulation on incorporation of phosphate and methionine into proteins of isolated lymph node cells.

M KERN, H N EISEN.   

Abstract

Isolated lymph node cells incorporate inorganic orthophosphate into a protein fraction. The phosphorylated product is a phosphoprotein. The rate of phosphate incorporation into phosphoprotein was determined in cells isolated from regional lymph nodes at varying times after antigen injection. The rate was unaltered on the 3rd day, but was enhanced on the 4th day after injection. Parallel results were obtained with L-methionine incorporation into the same gross protein fraction. Possible relationships between antibody formation and the observed enhancement in phosphate incorporation into phosphoprotein are discussed.

Entities:  

Keywords:  LYMPH NODES/metabolism; PHOSPHATES/metabolism; PROTEINS/metabolism

Mesh：

Substances：

Year:  1959        PMID： 13673135      PMCID： PMC2136988          DOI： 10.1084/jem.110.2.207

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  13 in total

1.  Analysis of leukocytic extracts from guinea pigs hypersensitive to tuberculin and 2,4-dinitrochlorobenzene.

Authors:  W S JETER; K A LAURENCE; P M SEEBOHM
Journal:  J Bacteriol       Date:  1957-11       Impact factor: 3.490

2.  The linkage of phosphate to protein in pepsin and ovalbumin.

Authors:  M FLAVIN
Journal:  J Biol Chem       Date:  1954-10       Impact factor: 5.157

3.  Studies of hypersensitivity to low molecular weight substances. III. The 2,4-dinitrophenyl group as a determinant in the preciptin reaction.

Authors:  H N EISEN; M E CARSTEN; S BELMAN
Journal:  J Immunol       Date:  1954-11       Impact factor: 5.422

4.  Nutrition needs of mammalian cells in tissue culture.

Authors:  H EAGLE
Journal:  Science       Date:  1955-09-16       Impact factor: 47.728

5.  Passive transfer of delayed hypersensitivity to 2,4-dinitrochlorobenzene in guinea pigs with leucocytic extracts.

Authors:  W S JETER; M M TREMAINE; P M SEEBOHM
Journal:  Proc Soc Exp Biol Med       Date:  1954-06

6.  The chromatographic identification of some biologically important phosphate esters.

Authors:  R S BANDURSKI; B AXELROD
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

7.  Separation of the phosphoric esters on the filter paper chromatogram.

Authors:  C S HANES; F A ISHERWOOD
Journal:  Nature       Date:  1949-12-31       Impact factor: 49.962

8.  The transfer of lymph node cells in the study of the immune response to foreign proteins.

Authors:  J C ROBERTS; F J DIXON
Journal:  J Exp Med       Date:  1955-10-01       Impact factor: 14.307

9.  Histochemical changes in lymphocytes during the production of antibodies in lymph nodes of rabbits.

Authors:  T N HARRIS; S HARRIS
Journal:  J Exp Med       Date:  1949-08-01       Impact factor: 14.307

10.  A study of the distribution of 2,4-dinitrobenzene sensitizers between isolated lymph node cells and extracellular medium in relation to induction of contact skin sensitivity.

Authors:  H N EISEN; M KERN; W T NEWTON; E HELMREICH
Journal:  J Exp Med       Date:  1959-08-01       Impact factor: 14.307
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  9 in total

1.  Liver sinusoidal cells. Identification of a subpopulation for erythrocyte catabolism.

Authors:  D M Bissell; L Hammaker; R Schmid
Journal:  J Cell Biol       Date:  1972-07       Impact factor: 10.539

2.  Cell-to-cell interaction in the immune response. VI. Contribution of thymus-derived cells and antibody-forming cell precursors to immunological memory.

Authors:  J F Miller; J Sprent
Journal:  J Exp Med       Date:  1971-07-01       Impact factor: 14.307

3.  Cell to cell interaction in the immune response. V. Target cells for tolerance induction.

Authors:  J F Miller; G F Mitchell
Journal:  J Exp Med       Date:  1970-04-01       Impact factor: 14.307

4.  HOMEOSTASIS OF ANTIBODY FORMATION IN THE ADULT RAT.

Authors:  D A ROWLEY; F W FITCH
Journal:  J Exp Med       Date:  1964-12-01       Impact factor: 14.307

5.  Effect of recent antigen priming on adoptive immune responses. I. Specific unresponsiveness of cells from lymphoid organs of mice primed with heterologous erythrocytes.

Authors:  J Sprent; J F Miller
Journal:  J Exp Med       Date:  1973-07-01       Impact factor: 14.307

6.  Cell-to-cell interaction in the immune response. VII. Requirement for differentiation of thymus-derived cells.

Authors:  J F Miller; J Sprent; A Basten; N L Warner; J C Breitner; G Rowland; J Hamilton; H Silver; W J Martin
Journal:  J Exp Med       Date:  1971-11-01       Impact factor: 14.307

7.  A study of the distribution of 2,4-dinitrobenzene sensitizers between isolated lymph node cells and extracellular medium in relation to induction of contact skin sensitivity.

Authors:  H N EISEN; M KERN; W T NEWTON; E HELMREICH
Journal:  J Exp Med       Date:  1959-08-01       Impact factor: 14.307

8.  A receptor for antibody on B lymphocytes. I. Method of detection and functional significance.

Authors:  A Basten; J F Miller; J Sprent; J Pye
Journal:  J Exp Med       Date:  1972-03-01       Impact factor: 14.307

9.  Induction of delayed-type hypersensitivity to azobenzenearsonate by a monoclonal anti-idiotype antibody.

Authors:  W R Thomas; G Morahan; I D Walker; J F Miller
Journal:  J Exp Med       Date:  1981-03-01       Impact factor: 14.307
  9 in total

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