Literature DB >> 1367260

Expression of active recombinant human alpha 1-antitrypsin in transgenic rabbits.

M Massoud1, R Bischoff, W Dalemans, H Pointu, J Attal, H Schultz, D Clesse, M G Stinnakre, A Pavirani, L M Houdebine.   

Abstract

A DNA construct containing the human alpha 1-antitrypsin gene including 1.5 and 4 kb of 5' and 3' flanking sequences, was microinjected into the pronucleus of rabbit embryos. The recombinant human protein was (a) expressed in the blood circulation of F0 and F1 transgenic rabbits at an average concentration of 1 mg ml-1, (b) shown to be fully active and (c) shown to be separable from its rabbit counterpart. Transgenic rabbits might represent a novel source of human proteins of therapeutic interest.

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Year:  1991        PMID： 1367260     DOI： 10.1016/0168-1656(91)90247-s

Source DB:  PubMed          Journal:  J Biotechnol        ISSN： 0168-1656            Impact factor:   3.307


  9 in total

Review 1.  The transgenic animal platform for biopharmaceutical production.

Authors:  L R Bertolini; H Meade; C R Lazzarotto; L T Martins; K C Tavares; M Bertolini; J D Murray
Journal:  Transgenic Res       Date:  2016-01-28       Impact factor: 2.788

2.  Enhancement of Alpha 1-antitrypsin Production in Pichia pastoris by Designing and Optimizing Medium Using Elemental Analysis.

Authors:  Tina Tavasoli; Sareh Arjmand; Seyed Omid Ranaei Siadat; Seyed Abbas Shojaosadati; Abbas Sahebghadam Lotfi
Journal:  Iran J Biotechnol       Date:  2017-12-29       Impact factor: 1.671

Review 3.  Immunoaffinity chromatography.

Authors:  G W Jack
Journal:  Mol Biotechnol       Date:  1994-02       Impact factor: 2.695

4.  Expression of human growth hormone in the milk of transgenic rabbits with transgene mapped to the telomere region of chromosome 7q.

Authors:  Daniel Lipinski; Joanna Zeyland; Marlena Szalata; Andrzej Plawski; Malgorzata Jarmuz; Jacek Jura; Aleksandra Korcz; Zdzislaw Smorag; Marek Pienkowski; Ryszard Slomski
Journal:  J Appl Genet       Date:  2012-08-17       Impact factor: 3.240

Review 5.  Transgenic animal bioreactors.

Authors:  L M Houdebine
Journal:  Transgenic Res       Date:  2000       Impact factor: 2.788

Review 6.  Transgenic milk as a method for the production of recombinant antibodies.

Authors:  D P Pollock; J P Kutzko; E Birck-Wilson; J L Williams; Y Echelard; H M Meade
Journal:  J Immunol Methods       Date:  1999-12-10       Impact factor: 2.303

7.  Expression systems and species used for transgenic animal bioreactors.

Authors:  Yanli Wang; Sihai Zhao; Liang Bai; Jianglin Fan; Enqi Liu
Journal:  Biomed Res Int       Date:  2013-03-17       Impact factor: 3.411

8.  Expression and Purification of Functionally Active Recombinant Human Alpha 1-Antitrypsin in Methylotrophic Yeast Pichia pastoris.

Authors:  Sareh Arjmand; Elham Bidram; Abbas Sahebghadam Lotfi; Mehdi Shamsara; Seyed Javad Mowla
Journal:  Avicenna J Med Biotechnol       Date:  2011-07

9.  Identification and characterization of rabbit ROSA26 for gene knock-in and stable reporter gene expression.

Authors:  Dongshan Yang; Jun Song; Jifeng Zhang; Jie Xu; Tianqing Zhu; Zhong Wang; Liangxue Lai; Y Eugene Chen
Journal:  Sci Rep       Date:  2016-04-27       Impact factor: 4.379
  9 in total

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