Literature DB >> 1366902

Controlled release of interleukin-2 from biodegradable microspheres.

M S Hora1, R K Rana, J H Nunberg, T R Tice, R M Gilley, M E Hudson.   

Abstract

We have evaluated the use of biodegradable poly(DL-lactide-co-glycolide) microspheres for the controlled release of interleukin-2 (IL-2) and its modified forms: succinyl IL-2 (SIL-2) and polyethylene glycol-modified IL-2 (PEG IL-2). We show that a microsphere formulation can be prepared from PEG IL-2 using HSA as an excipient which, after an initial burst, releases 2-3% PEG IL-2 per day in a bioactive form continuously over a 20- to 30-day period.

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Year:  1990        PMID： 1366902     DOI： 10.1038/nbt0890-755

Source DB:  PubMed          Journal:  Biotechnology (N Y)        ISSN： 0733-222X


  10 in total

1.  Biological activity of interleukin-2 bound to Candida albicans.

Authors:  C B Treseler; R T Maziarz; S M Levitz
Journal:  Infect Immun       Date:  1992-01       Impact factor: 3.441

Review 2.  Synthetic nanovaccines for immunotherapy.

Authors:  Min Luo; Layla Z Samandi; Zhaohui Wang; Zhijian J Chen; Jinming Gao
Journal:  J Control Release       Date:  2017-03-21       Impact factor: 9.776

3.  Controlled local delivery of interleukin-2 by biodegradable polymers protects animals from experimental brain tumors and liver tumors.

Authors:  J Hanes; A Sills; Z Zhao; K W Suh; B Tyler; F DiMeco; D J Brat; M A Choti; K W Leong; D M Pardoll; H Brem
Journal:  Pharm Res       Date:  2001-07       Impact factor: 4.200

4.  Modulation of protein aggregation by polyethylene glycol conjugation: GCSF as a case study.

Authors:  Rahul S Rajan; Tiansheng Li; Mohini Aras; Christopher Sloey; Weston Sutherland; Hiromi Arai; Robert Briddell; Olaf Kinstler; Alexis M K Lueras; Yu Zhang; Heather Yeghnazar; Michael Treuheit; David N Brems
Journal:  Protein Sci       Date:  2006-04-05       Impact factor: 6.725

5.  In vitro and in vivo evaluation of topical formulations of spantide II.

Authors:  Loice Kikwai; R Jayachandra Babu; Renata Prado; Alexandra Kolot; Cheryl A Armstrong; John C Ansel; Mandip Singh
Journal:  AAPS PharmSciTech       Date:  2005-10-31       Impact factor: 3.246

Review 6.  Particle-mediated delivery of cytokines for immunotherapy.

Authors:  David A Christian; Christopher A Hunter
Journal:  Immunotherapy       Date:  2012-04       Impact factor: 4.196

7.  Controlled delivery of diphtheria toxoid using biodegradable poly(D,L-lactide) microcapsules.

Authors:  M Singh; A Singh; G P Talwar
Journal:  Pharm Res       Date:  1991-07       Impact factor: 4.200

Review 8.  Interleukin-2. A review of its pharmacological properties and therapeutic use in patients with cancer.

Authors:  Ruth Whittington; Diana Faulds
Journal:  Drugs       Date:  1993-09       Impact factor: 9.546

Review 9.  Biomaterial Strategies for Immunomodulation.

Authors:  Nathan A Hotaling; Li Tang; Darrell J Irvine; Julia E Babensee
Journal:  Annu Rev Biomed Eng       Date:  2015-09-29       Impact factor: 9.590

Review 10.  Nanoparticle Vaccines Against Infectious Diseases.

Authors:  Rashmirekha Pati; Maxim Shevtsov; Avinash Sonawane
Journal:  Front Immunol       Date:  2018-10-04       Impact factor: 7.561
  10 in total

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