Literature DB >> 13668519

Effect of diisopropylfluorophosphate on sulfhydryl proteases.

R M HEINICKE, R MORI.   

Abstract

Diisopropylfluorophosphate inhibited all the sulfhydryl proteases studied in our tests. This inhibition was most pronounced at pH 6.0. By first blocking the sulfhydryl group with p-chloromercuribenzoate, inhibition could be prevented. Neither cysteine nor choline gave appreciable reactivation of diisopropylfluorophosphate-inhibited bromelain.

Entities:  

Keywords:  ISOFLUROPHATE/effects; PROTEASES

Mesh：

Substances：

Year:  1959        PMID： 13668519     DOI： 10.1126/science.129.3364.1678

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  4 in total

1.  THE ROLE IN ANAPHYLAXIS OF A CHYMOTRYPSIN-LIKE ENZYME IN RAT MAST CELLS.

Authors:  B A PERERA; J L MONGAR
Journal:  Immunology       Date:  1963-09       Impact factor: 7.397

2.  A factor X-activating cysteine protease from malignant tissue.

Authors:  S G Gordon; B A Cross
Journal:  J Clin Invest       Date:  1981-06       Impact factor: 14.808

3.  Catalytic site cysteines of thiol enzyme: sulfurtransferases.

Authors:  Noriyuki Nagahara
Journal:  J Amino Acids       Date:  2010-12-28

4.  Anaphylaxis in chopped guinea pig lung. I. Effect of peptidase substrates and inhibitors.

Authors:  K F AUSTEN; W E BROCKLEHURST
Journal:  J Exp Med       Date:  1961-03-01       Impact factor: 14.307
  4 in total

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