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Literature DB >> 136668

Autonomic actions and interactions of mianserin hydrochloride (Org. GB 94) and amitriptyline in patients with depressive illness.

Abstract

The clinical pharmacology of mianserin hydrochloride was studied in patients suffering from a primary depressive illness after steady-state plasma concentration of the drug had been achieved. The results were compared with those found with amitriptyline in both open and double-blind studies. The two drugs are equally effective in their antidepressive effect. Mianserin hydrochloride appears to be free of anticholinergic effects as assessed by the measurement of salivary volume, pupil diameter and the interactions with guanethidine and thymoxamine on the pupil. No peripheral adrenergic interaction as studied by the tyramine dose-pressor-response test were observed in patients treated with mianserin hydrochloride (20 mg three times daily).

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Year: 1976 PMID： 136668 DOI： 10.1007/bf00427291

Source DB: PubMed Journal: Psychopharmacology (Berl) ISSN： 0033-3158 Impact factor: 4.530

11 in total

1. The action of sympathomimetic amines in animals treated with reserpine.

Authors: J H BURN; M J RAND
Journal: J Physiol Date: 1958-12-04 Impact factor: 5.182

2. A rating scale for depression.

Authors: M HAMILTON
Journal: J Neurol Neurosurg Psychiatry Date: 1960-02 Impact factor: 10.154

3. Interactions of amitriptyline with guanethidine and thymoxamine in the human iris.

Authors: K Ghose; C Dobree; P Taylor; P Turner
Journal: Br J Clin Pharmacol Date: 1974-12 Impact factor: 4.335

4. Studies of the interaction of desmethylimipramine with tyramine in man after a single oral dose, and its correlation with plasma concentration.

Authors: K Ghose; L A Gifford; P Turner; M Leighton
Journal: Br J Clin Pharmacol Date: 1976-04 Impact factor: 4.335

5. Proceedings: The effects of a new anti-depressant, ORG GB94, on amine uptake mechanisms.

Authors: I Goodlet; M F Sugrue
Journal: Br J Pharmacol Date: 1974-11 Impact factor: 8.739

6. Class experiment in clinical pharmacology with benzilonium bromide, an anticholinergic drug.

Authors: P J Kingsley; P Turner
Journal: Eur J Clin Pharmacol Date: 1974 Impact factor: 2.953

7. A noel type of substituted piperazine with high antiserotonin potency.

Authors: W J van der Burg; I L Bonta; J Delobelle; C Ramon; B Vargaftig
Journal: J Med Chem Date: 1970-01 Impact factor: 7.446

8. Mianserin hydrochloride: a novel antidepressant.

Authors: A Coppen; R Gupta; S Montgomery; K Ghose; J Bailey; B Burns; J J de Ridder
Journal: Br J Psychiatry Date: 1976-10 Impact factor: 9.319

9. Intravenous tyramine pressor response in depression.

Authors: K Ghose; P Turner
Journal: Lancet Date: 1975-06-14 Impact factor: 79.321

10. Steady-state plasma levels of nortriptyline in twins: influence of genetic factors and drug therapy.

Authors: B Alexanderson; D A Evans; F Sjöqvist
Journal: Br Med J Date: 1969-12-27

31 in total

Review 1. Tricyclic antidepressant pharmacology and therapeutic drug interactions updated.

Authors: P K Gillman
Journal: Br J Pharmacol Date: 2007-04-30 Impact factor: 8.739

2. Effects of antidepressants on the intraventricular conduction and the incidence of arrhythmias induced by programmed ventricular stimulation in the dog heart after myocardial infarction.

Authors: M Nishimoto; H Hashimoto; T Ozaki; S Nagashima; M Nakashima
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1990-03 Impact factor: 3.000

3. Assessment of the anticholinergic effects of antidepressants in a single-dose cross-over study of salivation and plasma levels.

Authors: L Clemmesen; P L Mikkelsen; H Lund; T G Bolwig; O J Rafaelsen
Journal: Psychopharmacology (Berl) Date: 1984 Impact factor: 4.530

Autonomic actions and interactions of mianserin hydrochloride (Org. GB 94) and amitriptyline in patients with depressive illness.

1. The action of sympathomimetic amines in animals treated with reserpine.

2. A rating scale for depression.

3. Interactions of amitriptyline with guanethidine and thymoxamine in the human iris.

4. Studies of the interaction of desmethylimipramine with tyramine in man after a single oral dose, and its correlation with plasma concentration.

5. Proceedings: The effects of a new anti-depressant, ORG GB94, on amine uptake mechanisms.

6. Class experiment in clinical pharmacology with benzilonium bromide, an anticholinergic drug.

7. A noel type of substituted piperazine with high antiserotonin potency.

8. Mianserin hydrochloride: a novel antidepressant.

9. Intravenous tyramine pressor response in depression.

10. Steady-state plasma levels of nortriptyline in twins: influence of genetic factors and drug therapy.

Review 1. Tricyclic antidepressant pharmacology and therapeutic drug interactions updated.

2. Effects of antidepressants on the intraventricular conduction and the incidence of arrhythmias induced by programmed ventricular stimulation in the dog heart after myocardial infarction.

3. Assessment of the anticholinergic effects of antidepressants in a single-dose cross-over study of salivation and plasma levels.

4. Cardiovascular effects of amitriptyline, mianserin, zimelidine and nomifensine in depressed patients.

5. Mianserin: a decade of scientific development.

Review 6. Mianserin: a review of its pharmacological properties and therapeutic efficacy in depressive illness.

7. Mianserin, maprotiline and intracardiac conduction.

8. Cardiovascular responses to mianserin hydrochloride: a comparison with tricyclic antidepressant drugs.

9. Clinical study of mianserin, imipramine and placebo in depression: blood level and MHPG correlations.

10. Anticholinergic and blood pressure effects of mianserin, amitriptyline and placebo.