Literature DB >> 1366663

Industrial production of monoclonal antibodies and therapeutic proteins by dialysis fermentation.

M J Comer1, M J Kearns, J Wahl, M Munster, T Lorenz, B Szperalski, S Koch, U Behrendt, H Brunner.   

Abstract

A novel and powerful fermentation method is reported for the large-scale growth of mammalian cells and their secreted products. The system described illustrates many of the advantages of conventional batch fermentation processes but in addition has been shown to yield cell densities in excess of 1 x 10(7) cells/ml with concomitant increase in product concentration.

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Year:  1990        PMID： 1366663     DOI： 10.1007/bf00365493

Source DB:  PubMed          Journal:  Cytotechnology        ISSN： 0920-9069            Impact factor:   2.058


  6 in total

1.  Continuous cultures of fused cells secreting antibody of predefined specificity.

Authors:  G Köhler; C Milstein
Journal:  Nature       Date:  1975-08-07       Impact factor: 49.962

2.  Cell culture on artificial capillaries: an approach to tissue growth in vitro.

Authors:  R A Knazek; P M Gullino; P O Kohler; R L Dedrick
Journal:  Science       Date:  1972-10-06       Impact factor: 47.728

3.  Growth of cell-strains and primary cells on micro-carriers in homogeneous culture.

Authors:  A L van Wezel
Journal:  Nature       Date:  1967-10-07       Impact factor: 49.962

4.  Factors affecting cell growth and monoclonal antibody production in stirred reactors.

Authors:  S Reuveny; D Velez; J D Macmillan; L Miller
Journal:  J Immunol Methods       Date:  1986-01-22       Impact factor: 2.303

5.  Large-scale rotating filter perfusion system for high-density growth of mammalian suspension cultures.

Authors:  W R Tolbert; J Feder; R C Kimes
Journal:  In Vitro       Date:  1981-10

6.  Microencapsulated islets as bioartificial endocrine pancreas.

Authors:  F Lim; A M Sun
Journal:  Science       Date:  1980-11-21       Impact factor: 47.728
  6 in total
  6 in total

1.  Determination of division rates of rCHO cells in high density and immobilized fermentation systems by flow cytometry.

Authors:  N Borth; M Reiter; G Blüml; C Schmatz; T Gaida; H Katinger
Journal:  Cytotechnology       Date:  1992       Impact factor: 2.058

2.  Growth limitation in hybridoma cell cultures: the role of inhibitory or toxic metabolites.

Authors:  O W Rønning; M Schartum; A Winsnes; G Lindberg
Journal:  Cytotechnology       Date:  1991-09       Impact factor: 2.058

3.  Influence of bcl-2 on antibody productivity in high cell density perfusion cultures of hybridoma.

Authors:  D Fassnacht; S Rössing; R P Singh; M Al-Rubeai; R Pörtner
Journal:  Cytotechnology       Date:  1999-07       Impact factor: 2.058

4.  Analysis of the use of fortified medium in continuous culture of mammalian cells.

Authors:  A Gambhir; C Zhang; A Europa; W S Hu
Journal:  Cytotechnology       Date:  1999-11       Impact factor: 2.058

5.  Increase of hybridoma productivity using an original dialysis culture system.

Authors:  B Mathiot; A Perani; D Dumas; M Maugras; J Didelon; J F Stoltz
Journal:  Cytotechnology       Date:  1993       Impact factor: 2.058

6.  Mass spectrometry: a tool for on-line monitoring of animal cell cultures.

Authors:  U Behrendt; S Koch; D D Gooch; U Steegmans; M J Comer
Journal:  Cytotechnology       Date:  1994       Impact factor: 2.058
  6 in total

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