Literature DB >> 1366623

Phosphate control sequences involved in transcriptional regulation of antibiotic biosynthesis.

P Liras1, J A Asturias, J F Martín.   

Abstract

The expression of genes encoding enzymes involved in antibiotic and other secondary metabolite biosynthesis is down-regulated by easily assimilable phosphate, carbon and nitrogen sources. Phosphate control of antibiotic production appears to act at the transcriptional level by a mechanism similar to that involved in control of phosphatases and other phosphate-regulated enzymes. A phosphate control (PC) sequence, strikingly similar to the phosphate control (pho) boxes of many bacterial genes, has been isolated from the phosphate regulated promoter that controls biosynthesis of the antibiotic candicidin, and characterized. From computer analysis of sequence data, PC sequences appear to be associated with promoter regions of several phosphate-controlled antibiotic biosynthetic genes.

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Year:  1990        PMID： 1366623     DOI： 10.1016/0167-7799(90)90170-3

Source DB:  PubMed          Journal:  Trends Biotechnol        ISSN： 0167-7799            Impact factor:   19.536


  15 in total

Review 1.  Phosphate control of the biosynthesis of antibiotics and other secondary metabolites is mediated by the PhoR-PhoP system: an unfinished story.

Authors:  Juan F Martín
Journal:  J Bacteriol       Date:  2004-08       Impact factor: 3.490

2.  Reciprocal Regulation of GlnR and PhoP in Response to Nitrogen and Phosphate Limitations in Saccharopolyspora erythraea.

Authors:  Li-Li Yao; Bang-Ce Ye
Journal:  Appl Environ Microbiol       Date:  2015-10-30       Impact factor: 4.792

3.  Streptomyces genetics in the 1990s.

Authors:  K F Chater
Journal:  World J Microbiol Biotechnol       Date:  1992-12       Impact factor: 3.312

Review 4.  Pseudomonas syringae phytotoxins: mode of action, regulation, and biosynthesis by peptide and polyketide synthetases.

Authors:  C L Bender; F Alarcón-Chaidez; D C Gross
Journal:  Microbiol Mol Biol Rev       Date:  1999-06       Impact factor: 11.056

5.  Regulation of ppk expression and in vivo function of Ppk in Streptomyces lividans TK24.

Authors:  Sofiane Ghorbel; Aleksey Smirnov; Hichem Chouayekh; Brice Sperandio; Catherine Esnault; Jan Kormanec; Marie-Joelle Virolle
Journal:  J Bacteriol       Date:  2006-09       Impact factor: 3.490

6.  Phosphate-controlled regulator for the biosynthesis of the dalbavancin precursor A40926.

Authors:  Rosa Alduina; Luca Lo Piccolo; Davide D'Alia; Clelia Ferraro; Nina Gunnarsson; Stefano Donadio; Anna Maria Puglia
Journal:  J Bacteriol       Date:  2007-09-14       Impact factor: 3.490

7.  The two-component PhoR-PhoP system controls both primary metabolism and secondary metabolite biosynthesis in Streptomyces lividans.

Authors:  A Sola-Landa; R S Moura; J F Martín
Journal:  Proc Natl Acad Sci U S A       Date:  2003-05-02       Impact factor: 11.205

8.  An integrated approach to studying regulation of production of the antibiotic methylenomycin by Streptomyces coelicolor A3(2).

Authors:  G Hobbs; A I Obanye; J Petty; J C Mason; E Barratt; D C Gardner; F Flett; C P Smith; P Broda; S G Oliver
Journal:  J Bacteriol       Date:  1992-03       Impact factor: 3.490

9.  Effects of replacement of promoters and modification of the leader peptide region of the amy gene of Streptomyces griseus on synthesis and secretion of alpha-amylase by Streptomyces lividans.

Authors:  T Vigal; J A Gil; A Daza; M D García-González; P Villadas; J F Martín
Journal:  Mol Gen Genet       Date:  1991-12

10.  Conditions for the production of jadomycin B by Streptomyces venezuelae ISP5230: effects of heat shock, ethanol treatment and phage infection.

Authors:  J L Doull; A K Singh; M Hoare; S W Ayer
Journal:  J Ind Microbiol       Date:  1994-03
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