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Literature DB >> 1366375

Characterization of peptidyl-nucleoside antifungal antibiotics from fermentation broth.

R Cooper¹, P Das, C Federbush, R Mierzwa, M Patel, B Pramanik, I Truumees.

Abstract

Characterization of sinefungin related antifungal antibiotics from fermentation broth was accomplished by coupling photodiode array (PDA) detection to high performance liquid chromatography (HPLC). From the combined HPLC-PDA evaluation of broth filtrate, we detected five sinefungin related components. Fast atom bombardment (FAB) mass spectroscopic evaluations, mass-analysed ion kinetic energy spectra (MIKES) and collision activated (CA) MIKES of these components confirmed their respective identities. Our findings from the combination of HPLC photodiode array acquisition and FAB-mass spectrometry suggest we have detected the presence of a previously unreported sinefungin analogue.

Entities: Chemical

Mesh：

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Year: 1990 PMID： 1366375 DOI： 10.1007/bf01569600

Source DB: PubMed Journal: J Ind Microbiol ISSN： 0169-4146

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References

8 in total

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Journal: J Antibiot (Tokyo) Date: 1973-08 Impact factor: 2.649

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Journal: J Antibiot (Tokyo) Date: 1973-08 Impact factor: 2.649

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Journal: J Chromatogr Date: 1983-12-30

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Authors: Y Tondeur; M Shorter; M E Gustafson; R C Pandey
Journal: Biomed Mass Spectrom Date: 1984-12

Characterization of peptidyl-nucleoside antifungal antibiotics from fermentation broth.

1. A9145, a new adenine-containing antifungal antibiotic. II. Biological activity.

2. A9145, a new adenine-containing antifungal antibiotic. I. Discovery and isolation.

3. On-line screening for drug metabolites by high-performance liquid chromatography with a diode array UV detector.

4. Fast atom bombardment mass spectrometry and tandem mass spectrometry in antibiotics: identification of nucleoside antitumor antibiotic toyocamycin in fermentation broth.

5. Screening for new microbial products by high-performance liquid chromatography using a photodiode array detector.

6. Photodiode array detection of peptide-nucleoside antibiotics.

7. Photodiode array ultraviolet spectrophotometric profiling of carboxylic acids in physiological fluids.

8. A9145, a new adenine-containing antifungal antibiotic: fermentation.