Literature DB >> 13662584

Pharmacological methods of estimating inhibition of drug oxidation in the mouse.

A W LESSIN.   

Abstract

Three pharmacological techniques for measuring inhibition of "non-specific" oxidase activity in the mouse are described: (1) potentiation of pentobarbitone hypnosis, (2) potentiation of chlorpromazine hypothermia; and (3) reduction in the toxicity of octamethylpyrophosphorodiamide (schradan). Iproniazid, isoniazid, and beta-diethylaminoethyl 3,3-diphenylpropylacetate (SKF 525A) gave comparable results in all three tests.

Entities:  

Keywords:  DRUGS/metabolism; OXIDASES

Mesh：

Substances：

Year:  1959        PMID： 13662584      PMCID： PMC1481781          DOI： 10.1111/j.1476-5381.1959.tb01394.x

Source DB:  PubMed          Journal:  Br J Pharmacol Chemother        ISSN： 0366-0826


  13 in total

1.  Antagonists to schradan poisoning in mice.

Authors:  R D O'BRIEN; A N DAVISON
Journal:  Can J Biochem Physiol       Date:  1958-11

2.  The hypothermic and sedative action of reserpine in the mouse.

Authors:  A W LESSIN; M W PARKES
Journal:  J Pharm Pharmacol       Date:  1957-10       Impact factor: 3.765

3.  The conversion of schra dan (OMPA) and parathion into inhibitors of cholinesterase by mammalian liver.

Authors:  A N DAVISON
Journal:  Biochem J       Date:  1955-10       Impact factor: 3.857

4.  On the mechanism of drug potentiation by iproniazid (2-isopropyl-1-isonicotinyl hydrazine).

Authors:  J R FOUTS; B B BRODIE
Journal:  J Pharmacol Exp Ther       Date:  1956-04       Impact factor: 4.030

5.  Mammalian conversion of octamethylpyrophosphoramide to a toxic phosphoramide N-oxide.

Authors:  J E CASIDA; T C ALLEN; M A STAHMANN
Journal:  J Biol Chem       Date:  1954-10       Impact factor: 5.157

6.  The effect of beta-diethylaminoethyl-diphenylpropylacetate hydrochloride (SKF No. 525-A) on hexobarbital.

Authors:  L COOK; J J TONER; E J FELLOWS
Journal:  J Pharmacol Exp Ther       Date:  1954-06       Impact factor: 4.030

7.  Mechanism of the potentiating action of beta-diethylaminoethyl diphenylpropylacetate.

Authors:  J AXELROD; J REICHENTHAL; B B BRODIE
Journal:  J Pharmacol Exp Ther       Date:  1954-09       Impact factor: 4.030

8.  Some problems in assessing the toxicity of the organophosphorus insecticides towards mammals.

Authors:  W N ALDRIDGE; J M BARNES
Journal:  Nature       Date:  1952-03-01       Impact factor: 49.962

9.  The Effect of Body Temperature on the Duration of Barbiturate Anesthesia in Mice.

Authors:  F A Fuhrman
Journal:  Science       Date:  1947-04-11       Impact factor: 47.728

10.  Studies on the toxicity and pharmacological action of octamethyl pyrophosphoramide (OMPA; Pestox III).

Authors:  K P DUBOIS; J DOULL; J M COON
Journal:  J Pharmacol Exp Ther       Date:  1950-07       Impact factor: 4.030
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  2 in total

1.  Inhibition of drug metabolism in the mouse by a hypocholesterolemic agent, AY-9944.

Authors:  A V Marton; C I Chappel
Journal:  Experientia       Date:  1964-09-15

2.  Prevention of the adrenocorticolytic actions of 7,12-dimethylbenz[a]anthracene and 7-hydroxymethyl-12-methylbenz[a]anthracene by beta-diethylaminoethyldiphenyl-n-propyl acetate (SKF 525-A).

Authors:  D N Wheatley
Journal:  Br J Exp Pathol       Date:  1968-02
  2 in total

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