Literature DB >> 13662567

Increase of 5-hydroxytryptamine in the rat brain by raunescine.

M K PAASONEN, N T KARKI.   

Abstract

The Rauwolfia alkaloid raunescine (5 mg./kg., intraperitoneally) increased the concentration of 5-hydroxytryptamine in the brains of rats after iproniazid pre-treatment. This was evident 3 to 4 hr. after raunescine administration. There was no general increase in the noradrenaline content of the brains. In the intestine, raunescine depleted the 5-hydroxytryptamine content by about 50% within 3 to 4 hr. if the animals had been pre-treated with iproniazid. Iproniazid did not increase the content of noradrenaline in the intestine.

Entities:  

Keywords:  BRAIN/metabolism; NICOTINIC ACID ISOMERS/effects; RAUWOLFIA ALKALOIDS/effects; SEROTONIN/metabolism

Mesh：

Substances：

Year:  1959        PMID： 13662567      PMCID： PMC1481783          DOI： 10.1111/j.1476-5381.1959.tb01377.x

Source DB:  PubMed          Journal:  Br J Pharmacol Chemother        ISSN： 0366-0826


  8 in total

1.  A concept for a role of serotonin and norepinephrine as chemical mediators in the brain.

Authors:  B B BRODIE; P A SHORE
Journal:  Ann N Y Acad Sci       Date:  1957-03-14       Impact factor: 5.691

2.  Biochemical findings relating to the action of serotonin.

Authors:  S UDENFRIEND; H WEISSBACH; D F BOGDANSKI
Journal:  Ann N Y Acad Sci       Date:  1957-03-14       Impact factor: 5.691

3.  Metabolism and storage of biogenic amines.

Authors:  H BLASCHKO
Journal:  Experientia       Date:  1957-01-15

4.  The effect of inhibition of amine oxidase in vivo on administered adrenaline, noradrenaline, tyramine and serotonin.

Authors:  S J CORNE; J D GRAHAM
Journal:  J Physiol       Date:  1957-02-15       Impact factor: 5.182

5.  The pyretogenic effect of 5-hydroxytryptophan and its comparison with that of ISD.

Authors:  A HORITA; J H GOGERTY
Journal:  J Pharmacol Exp Ther       Date:  1958-02       Impact factor: 4.030

6.  [Effects of isonicotinic acid hydrazide on 5-hydroxytryptamine metabolism in brain].

Authors:  A PLETSCHER
Journal:  Experientia       Date:  1956-12-15

7.  The distribution of substance P and 5-hydroxytryptamine in the central nervous system of the dog.

Authors:  A H AMIN; T B CRAWFORD; J H GADDUM
Journal:  J Physiol       Date:  1954-12-10       Impact factor: 5.182

8.  Effects of raunescine and isoraunescine on behaviour and on the 5-hydroxytryptamine and noradrenaline contents of brain.

Authors:  M K PAASONEN; P B DEWS
Journal:  Br J Pharmacol Chemother       Date:  1958-03
  8 in total
  1 in total

1.  Effects of temperature on the 5-hydroxytryptamine (serotonin) content of tissues.

Authors:  C C TOH
Journal:  J Physiol       Date:  1960-06       Impact factor: 5.182
  1 in total

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