Literature DB >> 1365526

Application of crystallography to the design of antiviral agents.

M G Rossmann1, M A McKinlay.   

Abstract

A historical review of x-ray crystallography introduces basic concepts and describes the potential of this science to the rational design of antiviral agents. Following a brief introduction to the study of antiviral compounds that inhibit early stages of rhino- and enteroviral infections, the impact of structural studies on rational drug design is discussed in relation to known viral structures.

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Year:  1992        PMID： 1365526

Source DB:  PubMed          Journal:  Infect Agents Dis        ISSN： 1056-2044


  3 in total

1.  The pentamer channel stiffening model for drug action on human rhinovirus HRV-1A.

Authors:  N Vaidehi; W A Goddard
Journal:  Proc Natl Acad Sci U S A       Date:  1997-03-18       Impact factor: 11.205

Review 2.  Virus receptors: implications for pathogenesis and the design of antiviral agents.

Authors:  L C Norkin
Journal:  Clin Microbiol Rev       Date:  1995-04       Impact factor: 26.132

Review 3.  The human rhinovirus: human-pathological impact, mechanisms of antirhinoviral agents, and strategies for their discovery.

Authors:  Judith M Rollinger; Michaela Schmidtke
Journal:  Med Res Rev       Date:  2011-01       Impact factor: 12.944
  3 in total

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