Literature DB >> 1364818

Peristalsis evoked by 5-HT and renzapride: evidence for putative 5-HT4 receptor activation.

D A Craig1, D E Clarke.   

Abstract

The effect of 5-hydroxytryptamine and renzapride was studied on the peristaltic reflex elicited in vitro in the guinea-pig ileum. Both agents evoked the reflex at subthreshold intraluminal pressures (50% of threshold) and were blocked by ICS 205-930 (3 microM), but not ondansetron (5 microM). This novel finding suggests strongly that the prokinetic action of renzapride and gut motility stimulating action of 5-hydroxytryptamine are mediated via agonism at the putative 5-HT4 receptor.

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Year:  1991        PMID： 1364818      PMCID： PMC1917936          DOI： 10.1111/j.1476-5381.1991.tb12211.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  6 in total

1.  Observations concerning the action of 5-hydroxytryptamine on the peristaltic reflex.

Authors:  E BULBRING; A CREMA
Journal:  Br J Pharmacol Chemother       Date:  1958-12

2.  Pharmacological characterization of a neuronal receptor for 5-hydroxytryptamine in guinea pig ileum with properties similar to the 5-hydroxytryptamine receptor.

Authors:  D A Craig; D E Clarke
Journal:  J Pharmacol Exp Ther       Date:  1990-03       Impact factor: 4.030

3.  Proposals for the classification and nomenclature of functional receptors for 5-hydroxytryptamine.

Authors:  P B Bradley; G Engel; W Feniuk; J R Fozard; P P Humphrey; D N Middlemiss; E J Mylecharane; B P Richardson; P R Saxena
Journal:  Neuropharmacology       Date:  1986-06       Impact factor: 5.250

4.  5-Methoxytryptamine and 2-methyl-5-hydroxytryptamine-induced desensitization as a discriminative tool for the 5-HT3 and putative 5-HT4 receptors in guinea pig ileum.

Authors:  D A Craig; R M Eglen; L K Walsh; L A Perkins; R L Whiting; D E Clarke
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1990-07       Impact factor: 3.000

5.  Human pharmacology of renzapride: a new gastrokinetic benzamide without dopamine antagonist properties.

Authors:  D H Staniforth; M Pennick
Journal:  Eur J Clin Pharmacol       Date:  1990       Impact factor: 2.953

6.  Peripheral neural serotonin receptors: identification and characterization with specific antagonists and agonists.

Authors:  G M Mawe; T A Branchek; M D Gershon
Journal:  Proc Natl Acad Sci U S A       Date:  1986-12       Impact factor: 11.205
  6 in total
  20 in total

1.  5-HT7 receptors mediate the inhibitory effect of 5-HT on peristalsis in the isolated guinea-pig ileum.

Authors:  Bishwa R Tuladhar; Lanbo Ge; Robert J Naylor
Journal:  Br J Pharmacol       Date:  2003-04       Impact factor: 8.739

Review 2.  Neuropharmacology of emesis in relation to clinical response.

Authors:  B Costall; R J Naylor
Journal:  Br J Cancer Suppl       Date:  1992-12

3.  Poster communications.

Authors: 
Journal:  Br J Pharmacol       Date:  1993-07       Impact factor: 8.739

4.  Increased defecation during stress or after 5-hydroxytryptophan: selective inhibition by the 5-HT(4) receptor antagonist, SB-207266.

Authors:  G J Sanger; M Yoshida; M Yahyah; K Kitazumi
Journal:  Br J Pharmacol       Date:  2000-06       Impact factor: 8.739

5.  5-HT4 receptor mediated facilitation of the emptying phase of the peristaltic reflex in the guinea-pig isolated ileum.

Authors:  B Costall; R J Naylor; B R Tuladhar
Journal:  Br J Pharmacol       Date:  1993-12       Impact factor: 8.739

6.  Antagonistic properties of McNeil-A-343 at 5-HT4 and 5-HT3 receptors.

Authors:  A Sagrada; G B Schiavi; E Cereda; H Ladinsky
Journal:  Br J Pharmacol       Date:  1994-11       Impact factor: 8.739

7.  A comparative study of functional 5-HT4 receptors in human colon, rat oesophagus and rat ileum.

Authors:  P G McLean; I M Coupar; P Molenaar
Journal:  Br J Pharmacol       Date:  1995-05       Impact factor: 8.739

8.  5-HT3 and 5-HT4 receptor-mediated facilitation of the emptying phase of the peristaltic reflex in the marmoset isolated ileum.

Authors:  B R Tuladhar; B Costall; R J Naylor
Journal:  Br J Pharmacol       Date:  1996-04       Impact factor: 8.739

9.  Pharmacological characterization of the 5-hydroxytryptamine receptor mediating relaxation in the rat isolated ileum.

Authors:  B R Tuladhar; B Costall; R J Naylor
Journal:  Br J Pharmacol       Date:  1996-09       Impact factor: 8.739

10.  Effects of cholinoceptor and 5-hydroxytryptamine3 receptor antagonism on erythromycin-induced canine intestinal motility disruption and emesis.

Authors:  X Y Qin; M A Pilot; H Thompson; M Scott
Journal:  Br J Pharmacol       Date:  1993-01       Impact factor: 8.739
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