Literature DB >> 13641573

The cytotoxic action of immune gamma globulin and complement on Krebs ascites tumor cells. I. Ultrastructural studies.

B GOLDBERG, H GREEN.   

Abstract

Electron microscopic studies of Krebs ascites tumor cells treated in vitro with rabbit immune gamma globulin revealed a distinctive alteration in the structure of the cellular surface membrane. The subsequent addition of complement to this system severely damaged the cytoplasmic matrix, mitochondria, and endoplasmic reticulum. This sequence of events provides a structural basis for the cytotoxic action of antibody and complement.

Entities:  

Keywords:  AGAMMAGLOBULINEMIA/effects; COMPLEMENT; NEOPLASMS/experimental

Mesh：

Substances：

Year:  1959        PMID： 13641573      PMCID： PMC2136969          DOI： 10.1084/jem.109.5.505

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  10 in total

1.  The cross reactions of antisera prepared against four human cell strains in continuous tissue culture.

Authors:  M N GOLDSTEIN
Journal:  J Immunol       Date:  1957-08       Impact factor: 5.422

2.  Electron microscope studies of ascites tumor cells.

Authors:  C C SELBY; J J BIESELE; C E GREY
Journal:  Ann N Y Acad Sci       Date:  1956-03-14       Impact factor: 5.691

3.  The action of cytotoxic antisera on the HeLa strain of human carcinoma.

Authors:  D G MILLER; T C HSU
Journal:  Cancer Res       Date:  1956-05       Impact factor: 12.701

4.  Cytotoxic effects of antitumor serum.

Authors:  R W WISSLER; M H FLAX
Journal:  Ann N Y Acad Sci       Date:  1957-12-16       Impact factor: 5.691

5.  The action of anti-Ehrlich ascites tumor antibody.

Authors:  M H FLAX
Journal:  Cancer Res       Date:  1956-09       Impact factor: 12.701

6.  Nutrition needs of mammalian cells in tissue culture.

Authors:  H EAGLE
Journal:  Science       Date:  1955-09-16       Impact factor: 47.728

7.  Structural changes produced in Brown-Pearce carcinoma cells by means of a specific antibody and complement.

Authors:  B KALFAYAN; J G KIDD
Journal:  J Exp Med       Date:  1953-01       Impact factor: 14.307

8.  The nuclear envelope; its structure and relation to cytoplasmic membranes.

Authors:  M L WATSON
Journal:  J Biophys Biochem Cytol       Date:  1955-05-25

9.  The antigenic composition of mouse ascites tumour cells using in vitro and gel-diffusion techniques.

Authors:  G C EASTY; E J AMBROSE
Journal:  Br J Cancer       Date:  1957-06       Impact factor: 7.640

10.  The role of a natural antibody in the rejection of mouse tumor cells by the chick embryo.

Authors:  H GREEN; A L LORINCZ
Journal:  J Exp Med       Date:  1957-07-01       Impact factor: 14.307
  10 in total
  41 in total

1.  DIFFERENCES IN THE MECHANISM OF IN VITRO IMMUNE HEMOLYSIS RELATED TO ANTIBODY SPECIFICITY.

Authors:  D A SEARS; R I WEED; S N SWISHER
Journal:  J Clin Invest       Date:  1964-05       Impact factor: 14.808

2.  Cytotoxic effects produced by the beta toxin of Clostridium welchii on guinea-pigs monocytes.

Authors:  D ALLAN
Journal:  Immunology       Date:  1963-01       Impact factor: 7.397

3.  [THE AGGLUTINATION TEST FOR DETERMINATION OF ANTIGENS IN CELL STRAINS].

Authors:  W O GROSS; E SPECHTMEYER
Journal:  Z Krebsforsch       Date:  1963-10-04

4.  THE EFFECTS OF ANTIBODIES ON CELLS. I. BIOCHEMICAL AND HISTOCHEMICAL EFFECTS OF ANTIBODIES AND COMPLEMENT ON ASCITES TUMOUR CELLS.

Authors:  D C DUMONDE; L BITENSKY; G J CUNNINGHAM; J CHAYEN
Journal:  Immunology       Date:  1965-01       Impact factor: 7.397

5.  Tissue culture studies of lymphoid tissue sensitized to skin homografts and explanted with donor tissue.

Authors:  J A SHARP; R G BURWELL
Journal:  J Anat       Date:  1962-10       Impact factor: 2.610

6.  [Research on the effect of complement cytolysin on cell metabolism].

Authors:  H FISCHER; C H VOGT; H HERRSCHAFT
Journal:  Klin Wochenschr       Date:  1963-01-01

7.  Immune cytolysis. 1. The release of ribonucleoprotein particles. 2. Membrane-bounded structures arising during cell fragmentation.

Authors:  B GOLDBERG; H GREEN
Journal:  J Biophys Biochem Cytol       Date:  1960-07

8.  The role of cellular swelling in the pathogenesis of organ ischemia.

Authors:  R L Jamison
Journal:  West J Med       Date:  1974-03

9.  Phospholipid synthesis in HeLa cells exposed to immunoglobulin G and complement.

Authors:  F Güttler
Journal:  Biochem J       Date:  1972-07       Impact factor: 3.857

10.  Successful short-term modification of hyperacute renal allograft rejection in the primate. Intrarenal effects of phenoxybenzamine and methylprednisolone combined with heparin.

Authors:  G J Busch; A C Martins; N K Hollenberg; R C Moretz; R E Wilson; R W Colman
Journal:  Am J Pathol       Date:  1976-01       Impact factor: 4.307
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