Literature DB >> 13635031

Drug metabolism in the newborn rabbit.

J R FOUTS, R H ADAMSON.   

Abstract

A number of drugs that are metabolized through the action of enzymes present in liver microsomes in the adult rabbit are not metabolized in livers of newborn rabbits. The development of metabolic pathways during a period of 4 weeks is presented. Evidence is given for the presence in livers of baby rabbits of inhibitors of some of these drug-enzyme systems.

Entities:  

Keywords:  DRUGS/metabolism

Mesh：

Substances：

Year:  1959        PMID： 13635031     DOI： 10.1126/science.129.3353.897

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  37 in total

1.  Anaesthesia in new-born animals.

Authors:  J A WEATHERALL
Journal:  Br J Pharmacol Chemother       Date:  1960-09

2.  [Effects of alpha-methyl-dopa on new born kitten sleep. Behavioral evolution during the first month post-birth (author's transl)].

Authors:  D Saucier; L Astic
Journal:  Psychopharmacologia       Date:  1975-06-19

Review 3.  Fetal drug metabolism and its possible clinical implications.

Authors:  B Krauer; P Dayer
Journal:  Clin Pharmacokinet       Date:  1991-07       Impact factor: 6.447

4.  Ontogeny of novel cytochrome P450 gene isoforms during postnatal liver maturation in mice.

Authors:  Julia Yue Cui; Helen J Renaud; Curtis D Klaassen
Journal:  Drug Metab Dispos       Date:  2012-03-23       Impact factor: 3.922

5.  Evidence for the possible formation of a toxic tyrosine metabolite by the liver microsomal drug metabolizing system.

Authors:  J C David
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1976       Impact factor: 3.000

6.  Developmental pharmacology and toxicology: biotransformation of drugs and other xenobiotics during postnatal development.

Authors:  Wolfgang Klinger
Journal:  Eur J Drug Metab Pharmacokinet       Date:  2005 Jan-Jun       Impact factor: 2.441

7.  Effect of benzo( )pyrene treatment on the benzo( )pyrene hydroxylase activity in maternal liver, placenta, and fetus of the rat during day 13 to day 18 of gestation.

Authors:  E Schlede; H J Merker
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1972       Impact factor: 3.000

8.  Variations in drug metabolism during mammalian development genetic aspects.

Authors:  D Neubert; H J Merker
Journal:  Humangenetik       Date:  1970

9.  [Drug uptake and catabolism in the fetal period].

Authors:  K J Netter
Journal:  Arch Gynakol       Date:  1971-06-04

10.  [Changes in the velocity of drug catabolism and their importance in drug therapy].

Authors:  G F Kahl
Journal:  Klin Wochenschr       Date:  1971-04-01
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