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Literature DB >> 13631204

Anesthetic and calcium action in the voltage-clamped squid giant axon.

A M SHANES, W H FREYGANG, H GRUNDFEST, E AMATNIEK.

Abstract

Changes in spike configuration and in the inward and outward currents of voltage-clamped axons agree in indicating that the increases in permeability to sodium and potassium ions during activity are depressed by procaine and cocaine and augmented by calcium. At low levels of depolarization, the effect of the multivalent ion is similar to that of the local anesthetics, in keeping with their similar effects on the threshold of excitability. The reduction of membrane conductance at rest requires a higher concentration of the drugs than that needed to affect the increase in permeability with activity.

Entities: Chemical

Keywords: ANESTHETICS, LOCAL/effects; CALCIUM/effects; NEURONS/physiology; POTASSIUM/metabolism; SODIUM/metabolism

Mesh：

Substances：

Year: 1959 PMID： 13631204 PMCID： PMC2195003 DOI： 10.1085/jgp.42.4.793

Source DB: PubMed Journal: J Gen Physiol ISSN： 0022-1295 Impact factor: 4.086

12 in total

1. The action of calcium on the electrical properties of squid axons.

Authors: B FRANKENHAEUSER; A L HODGKIN
Journal: J Physiol Date: 1957-07-11 Impact factor: 5.182

2. Discrete threshold and repetitive responses in the squid axon under voltage-clamp.

Authors: I TASAKI; A F BAK
Journal: Am J Physiol Date: 1958-05

3. Nonuniform response in the squid axon membrana under voltage-clamp.

Authors: I TASAKI; C S SPYROPOULOS
Journal: Am J Physiol Date: 1958-05

4. Electrochemical aspects of physiological and pharmacological action in excitable cells. I. The resting cell and its alteration by extrinsic factors.

Authors: A M SHANES
Journal: Pharmacol Rev Date: 1958-03 Impact factor: 25.468

5. Electrochemical aspects of physiological and pharmacological action in excitable cells. II. The action potential and excitation.

Authors: A M SHANES
Journal: Pharmacol Rev Date: 1958-06 Impact factor: 25.468

6. A quantitative description of membrane current and its application to conduction and excitation in nerve.

Authors: A L HODGKIN; A F HUXLEY
Journal: J Physiol Date: 1952-08 Impact factor: 5.182

7. Measurement of current-voltage relations in the membrane of the giant axon of Loligo.

Authors: A L HODGKIN; A F HUXLEY; B KATZ
Journal: J Physiol Date: 1952-04 Impact factor: 5.182

8. Currents carried by sodium and potassium ions through the membrane of the giant axon of Loligo.

Authors: A L HODGKIN; A F HUXLEY
Journal: J Physiol Date: 1952-04 Impact factor: 5.182

9. Kinetics of ion movement in the squid giant axon.

Authors: A M SHANES; M D BERMAN
Journal: J Gen Physiol Date: 1955-11-20 Impact factor: 4.086

10. Low level impedance changes following the spike in the squid giant axon before and after treatment with "veratrine" alkaloids.

Authors: A M SHANES; H GRUNDFEST; W FREYGANG
Journal: J Gen Physiol Date: 1953-09 Impact factor: 4.086

52 in total

1. [CONTRIBUTION TO THE MECHANISM OF ACTION OF LOCAL ANESTHETICS].

Authors: K KARZEL; M H DRAPER; H FRIEBEL
Journal: Naunyn Schmiedebergs Arch Exp Pathol Pharmakol Date: 1965-03-09

2. [The action potential of the isolated Ranvier's node during increases in the extracellular hydrogen ion concentration of calcium-rich and calcium-poor solutions].

Authors: R HEENE
Journal: Pflugers Arch Gesamte Physiol Menschen Tiere Date: 1962

Review 10. Tetrodotoxin: a brief history.

Authors: Toshio Narahashi
Journal: Proc Jpn Acad Ser B Phys Biol Sci Date: 2008 Impact factor: 3.493

Anesthetic and calcium action in the voltage-clamped squid giant axon.

1. The action of calcium on the electrical properties of squid axons.

2. Discrete threshold and repetitive responses in the squid axon under voltage-clamp.

3. Nonuniform response in the squid axon membrana under voltage-clamp.

4. Electrochemical aspects of physiological and pharmacological action in excitable cells. I. The resting cell and its alteration by extrinsic factors.

5. Electrochemical aspects of physiological and pharmacological action in excitable cells. II. The action potential and excitation.

6. A quantitative description of membrane current and its application to conduction and excitation in nerve.

7. Measurement of current-voltage relations in the membrane of the giant axon of Loligo.

8. Currents carried by sodium and potassium ions through the membrane of the giant axon of Loligo.

9. Kinetics of ion movement in the squid giant axon.

10. Low level impedance changes following the spike in the squid giant axon before and after treatment with "veratrine" alkaloids.

1. [CONTRIBUTION TO THE MECHANISM OF ACTION OF LOCAL ANESTHETICS].

2. [The action potential of the isolated Ranvier's node during increases in the extracellular hydrogen ion concentration of calcium-rich and calcium-poor solutions].

3. Some factors concerned in differential nerve block by local anaesthetics.

4. [The effect of calcium ions on the membrane potential of medullated nerve fibers].

5. [The after-potentials of isolated medullated nerve fibers of the frog in tetanic stimulation].

6. [The after-potential of isolated medullated nerve fibers of the frog following single irritation].

7. The action of procaine and atropine on spinal neurones.

8. Mechanism of the after-potential production in the giant axons of the cockroach.

9. GABA receptor-channel complex as a target site of mercury, copper, zinc, and lanthanides.

Review 10. Tetrodotoxin: a brief history.