Literature DB >> 136296

Pharmacology of antitumor agents from higher plants.

S M Sieber, J A Mead, R H Adamson.   

Abstract

Some pharmacologic properties of nine antitumor agents from higher plants are described. The agents are vincristine, vinblastine the epiodophyllotoxin derivatives VM-26 and VP-16-213, maytansine, bruceantin, thalicarpine, camptothecin, and lapachol. When sufficient information is available, the agents are discussed with regard to their antitumor activity, mechanism of action, pharmacologic disposition, structure-activity relationships, and toxicity.

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Year:  1976        PMID： 136296

Source DB:  PubMed          Journal:  Cancer Treat Rep        ISSN： 0361-5960


  7 in total

1.  Maytansinoid-antibody conjugates induce mitotic arrest by suppressing microtubule dynamic instability.

Authors:  Emin Oroudjev; Manu Lopus; Leslie Wilson; Charlene Audette; Carmela Provenzano; Hans Erickson; Yelena Kovtun; Ravi Chari; Mary Ann Jordan
Journal:  Mol Cancer Ther       Date:  2010-10       Impact factor: 6.261

2.  The Use of Small Molecules to Dissect Developmental and Regenerative Processes in Axolotls.

Authors:  Stéphane Roy
Journal:  Methods Mol Biol       Date:  2023

3.  [Etoposide VP 16--213)--a podophyllotoxinderivative with high antitumor activity (author's transl)].

Authors:  H J Schmoll; N Niederle; W Achterrath
Journal:  Klin Wochenschr       Date:  1981-11-02

Review 4.  Synthesis of Bisindole Alkaloids from the Apocynaceae Which Contain a Macroline or Sarpagine Unit: A Review.

Authors:  Md Toufiqur Rahman; Veera V N Phani Babu Tiruveedhula; James M Cook
Journal:  Molecules       Date:  2016-11-14       Impact factor: 4.411

5.  Kushui Rose (R. Setate x R. Rugosa) decoction exerts antitumor effects in C. elegans by downregulating Ras/MAPK pathway and resisting oxidative stress.

Authors:  Yan Liu; Dejuan Zhi; Xin Wang; Dongqing Fei; Zhanxin Zhang; Zhengrong Wu; Yang Li; Peng Chen; Hongyu Li
Journal:  Int J Mol Med       Date:  2018-06-21       Impact factor: 4.101

6.  Lapachol inhibits glycolysis in cancer cells by targeting pyruvate kinase M2.

Authors:  Mani Shankar Babu; Sailendra Mahanta; Alexander J Lakhter; Takashi Hato; Subhankar Paul; Samisubbu R Naidu
Journal:  PLoS One       Date:  2018-02-02       Impact factor: 3.240

Review 7.  A Review of the Structure-Activity Relationship of Natural and Synthetic Antimetastatic Compounds.

Authors:  Su Ki Liew; Sharan Malagobadan; Norhafiza M Arshad; Noor Hasima Nagoor
Journal:  Biomolecules       Date:  2020-01-14
  7 in total

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