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Literature DB >> 136250

3-oxo acid coenzyme A-transferase in normal and diabetic rat muscle.

Abstract

The amounts of succinyl-CoA--3-oxo acid CoA-transferase (EC 2.8.3.5) decrease progressively in skeletal muscle in streptozotocin-diabetic rats, reaching after 10 days about 50% of the value in normal rat muscle. Electrofocusing studies indicate the occurrence of partial proteolysis of the enzyme in diabetic muscle. However, several functional parameters relating to acetoacetate utilization, including substrate inhibition, are quite similar for muscle transferase preparations from normal and diseased rats. The development of pathological ketoacidosis is discussed in the light of these observations.

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Year: 1976 PMID： 136250 PMCID： PMC1163999 DOI： 10.1042/bj1580509

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

18 in total

3-oxo acid coenzyme A-transferase in normal and diabetic rat muscle.

1. The transport of monocarboxylic oxoacids in rat liver mitochondria.

2. Acetoacetic acid metabolism by skeletal muscle fibers from control and diabetic rats.

3. THE HYPOGLYCEMIC ACTION OF KETONES. II. EVIDENCE FOR A STIMULATORY FEEDBACK OF KETONES ON THE PANCREATIC BETA CELLS.

4. Enzymic determination of D(-)-beta-hydroxybutyric acid and acetoacetic acid in blood.

5. Acetoacetate coenzyme A transferase activity in rat hepatomas.

6. Protein measurement with the Folin phenol reagent.

7. Inhibition of muscle acetoacetate utilization during diabetic ketoacidosis.

8. A mitochondrial monocarboxylate transporter in rat liver and heart and its possible function in cell control.

9. Diabetogenic action of streptozotocin: relationship of dose to metabolic response.

10. The effect of acetoacetate on plasma insulin concentration.

1. Purification and properties of succinyl-coenzyme A-3-oxo acid coenzyme A-transferase from sheep kidney.

Review 2. Multi-dimensional Roles of Ketone Bodies in Fuel Metabolism, Signaling, and Therapeutics.

3. Initial-velocity kinetics of succinoyl-coenzyme A-3-oxo acid coenzyme A-transferase from sheep kidney.

Review 4. Ketone body metabolism and cardiovascular disease.