Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Release of autonomic mediators in cardiac tissue by suprathreshold stimulation.

Literature DB >> 13624723

Release of autonomic mediators in cardiac tissue by suprathreshold stimulation.

R F FURCHGOTT, T DE GUBAREFF, A GROSSMAN.

Abstract

Pharmacological evidence is presented supporting the theory that the increase in contractile strength of isolated cardiac muscle under suprathreshold stimulation is due to the release of an adrenergic mediator (norepinephrine). However, release of this material does not account for changes in contractile strength associated with changes in frequency of stimulation at threshold levels.

Entities: Chemical

Keywords: DEFECTS, CONGENITAL/physiology

Mesh：

Substances：
Norepinephrine

Year: 1959 PMID： 13624723 DOI： 10.1126/science.129.3345.328

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

Keyword Cloud
Cited

9 in total

1. Time- and rate-dependence of the inotropic action of noradrenaline in the isolated guinea-pig's atrium.

Authors: K l Baumann; H Reichel
Journal: Pflugers Arch Date: 1975 Impact factor: 3.657

2. Effect of mercuric chloride on contractility and transmembrane potential of the guinea-pig myocardium.

Authors: S Halbach
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1975 Impact factor: 3.000

3. [The effect of sodium ions in the relationship between frequency and force of the contraction of isolated guinea pig myocardium].

Authors: M Reiter
Journal: Naunyn Schmiedebergs Arch Pharmakol Exp Pathol Date: 1966

4. [The "contractibility" of the normal heart with pacemaker stimulation of the right ventricle].

Authors: R Jacob; G Kissling; E E Ohnhaus; U Peiper; J Segarra-Domenech
Journal: Arch Kreislaufforsch Date: 1967-12

5. Beta adrenergic receptor blockade of feline myocardium. Cardiac mechanics, energetics, and beta adrenoceptor regulation.

Authors: G Cooper; R L Kent; P McGonigle; A M Watanabe
Journal: J Clin Invest Date: 1986-02 Impact factor: 14.808

Release of autonomic mediators in cardiac tissue by suprathreshold stimulation.

1. Time- and rate-dependence of the inotropic action of noradrenaline in the isolated guinea-pig's atrium.

2. Effect of mercuric chloride on contractility and transmembrane potential of the guinea-pig myocardium.

3. [The effect of sodium ions in the relationship between frequency and force of the contraction of isolated guinea pig myocardium].

4. [The "contractibility" of the normal heart with pacemaker stimulation of the right ventricle].

5. Beta adrenergic receptor blockade of feline myocardium. Cardiac mechanics, energetics, and beta adrenoceptor regulation.

6. Endovascular neural stimulation via a novel basket electrode catheter: comparison of electrode configurations.

7. Influence of glyceryl trinitrate on force of contraction and action potential of guinea-pig myocardium.

8. The influence of drugs on the overflow of noradrenaline and the identification of receptors in guinea-pig atria.

9. Hemodynamic effects of ventricular defibrillation.